P物质在单眼剥夺性弱视猫视皮层中的表达  

Expressions of substance P in visual cortex in monocular deprivation cats

作　　者：王海燕 张东杲[2] 

机构地区：[1]解放军82医院眼科,江苏淮阴223001 [2]第四军医大学唐都医院眼科,西安710038

出　　处：《眼科新进展》2001年第4期235-237,共3页Recent Advances in Ophthalmology

摘　　要：目的　检测 P物质 (SP)在单眼剥夺弱视猫视皮层中的表达 ,并探讨其在弱视发病中的意义。方法　采用免疫组化 APA法 ,对 7例正常猫和 8例单眼剥夺弱视猫视皮层17区 SP免疫阳性神经元及神经纤维进行定位并定量研究其变化。结果　在单眼剥夺猫剥夺侧视皮层 17区 SP表达显著下降 (P <0 .0 5 )。结论　单眼剥夺可造成剥夺侧 17区剥夺眼相应输入层次的 SP表达下降 ,从而促进弱视的发生发展。Objective To investigate the changes of substance P ( SP ) in visual cortex area 17 in monocular deprivation cats , and discuss its role in the development of deprivation amblyopia. Methods Seven normal cats and eight monocular deprivation cats were processed by immunocytochemical method APA to demonstrate the localization of SP in area 17, and the data were analysed . Results In the monocular deprivation cats , the number and grey level of SP immunopositivity decreased greatly in ipsilateral layer 4 ( P <0.05).Conclusion Monocular deprivation in critical period of a newborn may lead to great changes of SP in visual cortex layer 4 , which receives imputs from the deprived eye.So it can play a role in the development of amblyopia.

关 键 词：P物质 弱视 视皮层 单眼剥夺 

分 类 号：R777.44[医药卫生—眼科]