食管癌组织的微血管密度及其临床病理意义  

Microvessel Density in Esophageal Carcinoma and its Clinicopathologic Significance

作　　者：殷智榕[1] 郝志芳[1] 高冬玲[1] 张云汉[1] 

机构地区：[1]河南医科大学第一附属医院病理科,河南郑州450052

出　　处：《咸宁医学院学报》2001年第2期89-91,共3页Journal of Xianning Medical College

摘　　要：目的探讨微血管密度在食管癌中的临床病理学意义。方法应用免疫组织化学SP法 ,对 65例食管鳞状细胞癌患者的手术切除标本 ,进行血管内皮细胞CD34 标记 ,计数 2 0 0×视野下 5个最高密度区的微血管数 ,取其均数计算微血管密度 (MVD)。分析MVD与不同临床病理因素之间的关系。结果MVD平均值为 31 .8± 1 0 .3,它与癌组织的浸润深度、淋巴结转移明显相关。Objective To determine whether tumor angiogenesis correlates with progression of esophageal carcinoma.Method Microvessel density (MVD) of 65 specimens resected from patients with esophageal squamous cell carcinoma were examined using immunohistochemical staining with CD 34 monoclonal antibody.Correlation among MVD and various clinicopathologic factors were studied.Result The mean MVD in 65 case of esophageal carcinoma was 31.8±10.3.MVD positively correlated with depth of invasion of carcinoma cells and lymph node metastasis.Conclusion MVD is one of the predictor for the biological behavior of esophageal squamous cell carcinoma.

关 键 词：食管癌 微血管密度 免疫组织化学 CD34 

分 类 号：R735.1[医药卫生—肿瘤]