Effect of Prolactin on Gonadotropin Regulation of Mouse Ovarian Function  

作　　者：胡召元 刘以训 

机构地区：[1]State Key Laboratory of Reproductive Biology, Institute of Zoology, Academia Sinica, Beijing 100080

出　　处：《Developmental and Reproductive Biology》1993年第2期26-32,共7页发育与生殖生物学报（英文版）

基　　金：The project is supported by Chinese Academy of Sciences;The State Family Planning Commission;The Natural Science Foundation of china;Rockefeller Foundation,New York.

摘　　要：We have demonstrated that prolactin inhibits gonadotropin-induced ovulation in PMSG-primed mice.The number of ova in oviducts considerably decreased in the group of hCG plus prolactin (PRL)(19.7 + 4.9) as compared with that of hCG alone (31.7 + 6.7). PRL inhibition of hCG-inducedovulation in mice may be through decreasing the ovarian plasminogen activator (PA) activity on onehand, and inhibiting the preovulatory increase in estrogen (E) secretion on the other.We have demonstrated that prolactin inhibits gonadotropin-induced ovulation in PMSG-primed mice. The number of ova in oviducts considerably decreased in the group of hCG plus prolactin (PRL) (19.7 + 4.9) as compared with that of hCG alone (31.7 + 6.7). PRL inhibition of hCG-induced ovulation in mice may be through decreasing the ovarian plasminogen activator (PA) activity on one hand, and inhibiting the preovulatory increase in estrogen (E) secretion on the other.

关 键 词：PROLACTIN MOUSE OVULATION Plasminogen Activator Estrogen. 

分 类 号：Q575.13[生物学—生物化学]