肝癌患者集束电极射频治疗后T淋巴细胞亚群及sIL-2R的改变  

Changes of Soluble Interleukin-2 Receptor and T lymphocytes Subsets in Patients with PHC After Rodiofrequency Ablation

作　　者：汪东文[1] 马庆久[1] 杜锡林[1] 贺舜民 鲁建国[1] 张盈华[1] 

机构地区：[1]第四军医大学唐都医院,710038 [2]武警湖南总队医院,410006

出　　处：《实用癌症杂志》2001年第4期348-349,359,共3页The Practical Journal of Cancer

摘　　要：目的　研究原发性肝癌患者集束电极 (多弹头 )射频治疗前后T细胞亚群及sIL 2R的变化及其临床意义。方法　采用免疫荧光染色法及ELISA双抗体夹心法 ,检测 40例原发性肝癌患者治疗前后的T细胞亚群及sIL 2R的改变 ,并与健康对照组比较。结果　肝癌组患者治疗前CD+ 3 和CD+ 4降低 ,CD+ 8和sIL 2R增高 ,CD+ 4/CD+ 8比值明显下降 ,与对照组比较 ,均有显著性差异 (P <0 .0 1)。肝癌组患者治疗后CD+ 3 和CD+ 4升高 ,CD+ 8和sIL 2R降低 ,CD+ 4/CD+ 8比值增高 ,治疗前后比较 ,有非常显著性差异 (P <0 .0 1)。结论　集束电极 (多弹头 )射频治疗可增强原发性肝癌患者机体免疫功能 ,提高其抗肿瘤能力。Objective To observe the changes of sIL-2R and T lymphocytes subsets in patients with PHC after radiofrequency ablation and evaluate their clinical significance.Methods Immune fluorescent assay and sandwich ELISA were used to measure the immune state of 40 patients with PHC before and after radiofrequency ablation and compared with health controls.Results CD+ 3,CD+ 4 and CD+ 4/CD+ 8 radio were significantly decreased,while the level of serum sIL-2R and CD+ 8 were significantly increased in patients with PHC as compared with those in normal individuals(P<0.01).The elevation of CD+ 3,CD+ 4 and CD+ 4/CD+ 8 radio(P<0.01),and the decline of sIL-2R level and CD+ 8(P<0.01) were observed in patients after radiofrequency ablation.Conclusion Rodiofrequency ablation can enhance the immune function of patients with PHC,and play an important role in the antitumor effect.

关 键 词：原发性肝癌 射频治疗 T细胞亚群 SIL-2R 

分 类 号：R735.7[医药卫生—肿瘤] R730.59[医药卫生—临床医学]