gst μ基因缺失与TNT白内障发病的关系  

A study on relationship between glutathione s-transferase μ gene deletion and trinitrotoluene cataract susceptibility

作　　者：许峻峰[1] 李昌吉[1] 龙云芳[1] 詹承烈[1] 王文静[2] 谯俊华[3] 李凤芝 杨定寿 

机构地区：[1]华西医科大学劳动卫生教研室,四川成都610041 [2]上海市疾病预防控制中心环境与职业医学科,上海200336 [3]四川省绵阳市卫生防疫站,四川绵阳621000 [4]河南省郑州市职业病防治研究所,河南郑州450053 [5]四川省绵阳市朝阳机械厂医院,四川绵阳621000

出　　处：《中国工业医学杂志》2001年第3期129-132,共4页Chinese Journal of Industrial Medicine

摘　　要：目的　探讨谷胱甘肽s 转移酶 μ基因 (Glutathiones transferaseμ ,gstμ)缺失与三硝基甲苯 (trinitrotoluene ,TNT)白内障发病的关系。方法　采用多聚酶链反应 (polymerasechainreaction ,PCR)方法 ,对TNT白内障患者、其他类型白内障患者、健康人群等 3组样本共 2 3 5人的DNA进行了gstμ基因检测。 结果　TNT白内障患者组gstμ基因缺失率高达 65 6% ,与各对照组比较差异均有显著性 (P <0 0 5 ) ,以健康人群为对照计算的gstμ基因缺失者发生TNT白内障的OR值为 2 3 3 ;gstμ基因缺失与TNT白内障的发生呈显著相关 (P <0 0 5 )。Objective To study the relationship between glutathione s transferase μ(gst μ)gene deletion and trinitrotoluene cataract(TC)susceptibility.Method Polymerase chain reaction(PCR)method was used to examine the rates of gst μ gene deletion in 154 cases of TC patients 41 cases of cataract patient by age or diabetes and 40 healthy persons.Results The rate of gst μ gene deletion in TC group was 68 58% which was significantly higher than that of other two groups——the non TNT cataract group(53 7%)and the healthy control group(45%)(P<0 05);the odds retio(OR)value based on the healthy control group is 2 33.Conclusion TC correlates closely with gst μ gene deletion,gst μ gene deletion may be one of the important hereditary factors for TC susceptibility.

关 键 词：三硝基甲苯 TNT白内障 tstμ基因缺失 晶体 

分 类 号：R776.1[医药卫生—眼科] Q754[医药卫生—临床医学]