微生物药物筛选研究进展  

Progresses in the screening of new microbial drugs

作　　者：司书毅[1] 黄明玉[1] 张月琴[1] 

机构地区：[1]中国医学科学院中国协和医科大学医药生物技术研究所国家新药筛选实验室,北京100050

出　　处：《基础医学与临床》2001年第4期294-297,共4页Basic and Clinical Medicine

摘　　要：Microbial drugs are antibiotics and other pharmacological substances from the secondary metabolites of microorganisms Screening process includes collection of soil and ocean samples, isolation of microorganisms, fermentation, strain screening, isolation of bioactive components and structure elucidation Producing microorganisms includes streptomyces, rare actinomycetes, bacteria, fungi, and ocean microorganisms New strategy for screening new microbial drugs is the screening of novel anti resistant bacterial agents, antifungal agents, antiviral agents, antitumor substances, immunomodulators and pharmacological activeMicrobial drugs are antibiotics and other pharmacological substances from the secondary metabolites of microorganisms Screening process includes collection of soil and ocean samples, isolation of microorganisms, fermentation, strain screening, isolation of bioactive components and structure elucidation Producing microorganisms includes streptomyces, rare actinomycetes, bacteria, fungi, and ocean microorganisms New strategy for screening new microbial drugs is the screening of novel anti resistant bacterial agents, antifungal agents, antiviral agents, antitumor substances, immunomodulators and pharmacological active substances

关 键 词：微生物药物 药物筛选 样品 微生物 发酵液 抗生素 

分 类 号：R965.1[医药卫生—药理学]