nm23-H1基因在甲状腺乳头状癌的表达及临床意义  

Expression of nm23-Hl in Papillary Carcinoma and Its Clinical Significance

作　　者：王旭东[1] 程文元[1] 高明[1] 刘经祖[1] 

机构地区：[1]天津医科大学附属肿瘤医院头颈科,300060

出　　处：《天津医药》2001年第9期526-528,共3页Tianjin Medical Journal

摘　　要：目的:探讨nm23-H1基因在甲状腺乳头状癌的表达及其与临床病理指标的关系。方法:采用免疫组化S-P法检测201例甲状腺乳头状癌,30例甲状腺良性增生及30例正常甲状腺组织中nm23-H1的表达情况。结果:(1)nm23-H1在甲状腺乳头状癌的表达阳性率为62.7％,明显低于两对照组(P<0.01或P<0.05)。(2)在甲状腺乳头状癌中,nm23-H1在Ⅰ型、Ⅱ型、Ⅲ型间及包膜内型、腺内型、腺外型间的表达均有显著性差异。(3)有淋巴结转移组nm23-H1的阳性率为54.5％,低于无淋巴结转移组(75.0％),其蛋白表达与颈淋巴结转移呈负相关。nm23-H1阴性表达的患者发生颈淋巴结转移的可能性大。结论:nm23-H1基因的表达与甲状腺乳头状癌的发生发展、浸润和颈淋巴结转移关系密切,检测mn23-H1可作为预测甲状腺乳头状癌颈淋巴,转移潜能的有价值的参考指标。To evaluate the expression of nm23-Hl in papillary carcinoma and its clinical significance. Methods: The expression of nm23-Hl were determined with immunohistochemical technique in biopsy specimen of papillary thyroid carcinoma (PTC)(n =201),benign thyroid proliferation(BTP)(n =30) and normal control (NC)(n =30). Results: 1. The positive rate of nm23-Hl in PTC was 62.7 % and significantly lower than that in BTP and NC( P<0.01orP<0.05).2. The positive rate of nm23-Hl in PTC with lymph node metastasis was significantly lower than that without lymph node metastasis. 3. The expression of nm23-Hl in PTC was negatively correlated with lymph node metastasis (P<0.01). The patients with nm23-Hl negative expression had the high possibility of neck lymph node metastasis. Conclusion: The expression of nm23-H1 is correlated with carcinogenesis, progression, infiltration and neck lymph node metastasis of PTC, and it can serve as an important indicator for predicting lymph node metastasis of PTC.

关 键 词：乳头状癌 甲状腺肿瘤 淋巴转移瘤 NM23-H1基因 

分 类 号：R736.1[医药卫生—肿瘤]