低龄肺癌患者手术后影响因素分析  

Analysis on the related factors influencing postoperative effect in young - middle aged patients with lung cancer

作　　者：崔少罡[1] 白玲[1] 常诚[1] 崔示德[1] 张昊[1] 张国强[2] 

机构地区：[1]解放军第264医院,太原030001 [2]第三军医大学附属新桥医院胸外科,重庆400037

出　　处：《临床肿瘤学杂志》2001年第2期144-146,共3页Chinese Clinical Oncology

摘　　要：目的:探讨低龄肺癌患者手术后疗效相关影响因素。方法:对118例低龄人肺癌手术后生存率进行回顾性调查,统计资料比较以x2处理。结果:总的1年生存率为34.75％（41/118）。手术方式中的袖式肺叶切除术后1年生存率为61.11％,与其它手术方式比较有显著差异性（x2=9.81,P<0.05）。TNM分期1年生存率分别为:Ⅰ期82.61％、Ⅱ期35.90％、Ⅲa期14.71％、Ⅲb期14.29％、Ⅳ期13.33％;Ⅰ期与Ⅱ期比较有极显著差异性（x2=10.87,P<0.01）,Ⅱ期与Ⅲa期比较有统计学意义（x2=4.24,P<0.05）,Ⅲa期、Ⅲb期和Ⅳ期间比较无差异性（P>0.05）。鳞癌1年生存率为73.08％,与其它病理类型比较有极显著差异性（x2=11.44,P<0.01）;大细胞癌1年生存率为7.41％,明显低于其它病理类型（x2=14.68,P<0.01）。结论:低龄人肺癌术后疗效与手术方式、TNM分期和病理类型有密切关系;早期明确诊断和袖式肺叶切除术可明显提高术后生存率;大细胞肺癌的治疗不宜首选外科手术方式。Objective: To explore the related factors that influenced the postoperative effect in young-middle aged patients with lung cancer.Methods:Survival rates of 118 cases of postoperative patients with lung cancer were reviewed retrospectively. The obtained data were statistically analysed by chi-square test. Results:The total one-year survival rate was 34.75% (41/118) . The one-year survival rate of the patients who received lung lobe sleeve-resection was 61.11%, and had great difference ( x2= 9.81, P <0.05), compared with the other operation manners. According to TNM classification, one-year survival rates ofⅠ ,Ⅱ ,Ⅲa, Ⅲb and Ⅳ stage were 82.61%, 35.90%, 14.71%, 14.29% and 13.33% respectively. The comparison of stage Ⅰ and Ⅱ showed very great difference(x2 = 10.87, P<0.01), the comparison of stage Ⅱ and Ⅲa had statistical significance(x2 = 4.24, P<0.05), the comparison among Ⅲ a, Ⅲb and Ⅳ periods showed little difference(P >0.05) . The one-year survival rate of squamous carcinoma was 73.08% and showed very greater difference with the other pathological types (x2 = 11.44, P<0.01). The one-year survival rate of large-cell carcinoma was 7.41% and apparently lower than the other pathological types( x2=14.68, P<0.01) . Conclusions; Post- operative effect of young-middle aged lung cancer is closely ralated to its operative manner, TNM classification and pathological types. Earlier definitive diagnosis and lung lobe sleeve - resection could apparently raised post - operative survival rate. Surgical therapy should not be first chosen for the large cell lung cancer.

关 键 词：肺肿瘤 低龄人 外科手术 预后因素 生存率 

分 类 号：R734.2[医药卫生—肿瘤] R730.56[医药卫生—临床医学]