膀胱移行细胞癌E-Cadherin和α-Catenin的表达及临床意义  

Expression of E-Cadherin and α-Catenin in bladder transitional cell carcinoma and its clinical significance

作　　者：张科[1] 谯体义[2] 邹永康[1] 唐伟[2] 杨晓华[1] 肖民辉[1] 李圆圆[3] 王德林[2] 

机构地区：[1]云南省第一人民医院泌尿外科,昆明650032 [2]重庆医科大学附属第一医院泌尿外科 [3]重庆医科大学病理学教研室

出　　处：《临床泌尿外科杂志》2001年第4期175-177,共3页Journal of Clinical Urology

摘　　要：目的 :探讨上皮钙粘素 (E- Cadherin)和α-连环素 (α- Catenin)在膀胱移行细胞癌中的表达及与其生物学行为之间的关系。方法 :采用免疫组织化学 SABC法检测 E- Cadherin和α- Catenin在 6 5例膀胱移行细胞癌石蜡标本中的表达。结果 :E- Cadherin在 G1 、G2 、G3级和 Tis～ T1 、T2 ～ T4期肿瘤中的正常表达率分别为 76 .2 %、34 .8%、4.8%和 5 4.1%、17.9% ,α- Catenin在 G1 、G2 、G3级和 Tis～ T1 、T2 ～ T4期肿瘤中的正常表达率分别为71.4%、34 .8%、4.8%和 5 1.4%、17.9% ,二者的表达情况均与肿瘤的病理分级和临床分期密切相关 (P <0 .0 1) ;6 5例肿瘤标本中 E- Cadherin和 α- Catenin表达同时正常或异常者占 83.1% ,二者表达之间具有显著相关性 (P<0 .0 1) ;E- Cadherin或 α- Catenin正常和异常表达者间癌复发率差异具有显著性意义 (P <0 .0 5 )。结论 :E-Cadherin和 α- Catenin的表达情况可以作为监测膀胱移行细胞癌恶性程度及复发的重要指标。Purpose:To detect the expression of E Cadherin and α Catenin in bladder transitional cell carcinoma (BTCC) and analyze its correlation with the biological behavior of BTCC.Methods:The immunohistochemical staining with strept avidin biotin peroxidase complex method (SABC method) was used to detect the expression of E Cadherin and α Catenin in 65 paraffin embeded BTCC tissues.Results:The normal expression rate of E Cadherin was 76.2 % of G 1, 34.8 % of G 2, 4.8 % of G 3, 54.1 % of T is ～T 1 and 17.9 % of T 2～T 4 tumors respectively.The normal expression rate of α Catenin was 71.4 % of G 1, 34.8 % of G 2, 4.8 % of G 3, 51.4 % of T is ～T 1 and 17.9 % of T 2～T 4 tumors respectively.The expression of either E Cadherin or α Catenin was significantly correlated with pathological grade,clinical stage of BTCC (P< 0.01 ).E Cadherin and α Catenin expression was concomitantly either normal or abnormal in 83.1 % of tumors.The correlation between E Cadherin and α Catenin expression was significant (P< 0.01 ).There was a significant difference in recurrence rate between normal E Cadherin expression team and abnormal E Cadherin expression team and between normal α Catenin expression team and abnormal α Catenin expression team (P< 0.05 ).Conclusions:Detection of E Cadherin and α Catenin expression have a practical significance in assessing the malignancy and recurrence of BTCC.

关 键 词：膀胱肿瘤 钙粘素 连环素 免疫组织化学 移行细胞癌 E-CADHERIN Α-CATENIN 

分 类 号：R737.14[医药卫生—肿瘤]