三音听觉P_(300)电位在老年期痴呆中的初步应用  

Preliminary application of three-tone paradigm auditory P_(300) in patients with senile dementia

作　　者：张晓君[1] 赵毅[1] 高玉红[1] 耿稚萍[1] 

机构地区：[1]首都医科大学附属北京同仁医院神经内科

出　　处：《临床神经电生理学杂志》2001年第3期135-138,共4页Journal of Clinical Electroneurophysiology

摘　　要：目的 :观察三音听觉P30 0 在老年期痴呆中的表现 ,探讨听觉P30 0 在老年期痴呆早期诊断中的临床应用价值。方法 :对 34例老年期痴呆患者进行传统听觉靶 /非靶刺激P30 0 电位 (2t P30 0 )和三音序列听觉P30 0 电位 (3t tP30 0 )的检测 ,并将二者结果进行比较。结果 :异常 2t P30 0 和 3t P30 0 的主要表现均为潜伏期延长、波形分化差和引不出肯定波形。 34例患者中 ,2t P30 0 异常者 18例 ,总异常率为 5 2 9%。其中 ,2 4例轻度痴呆者异常 9例 ,8例中度痴呆异常 7例 ,2例重度痴呆全部异常。 30例完成 3t P30 0 检测者 ,2 6例表现异常。其中 2 4例轻度痴呆异常 2 0例 ,中度 6例全部异常 ,总异常率为 86 7% ,与 2t P30 0 相比有极显著性差异。结论 :三音序列P30 0 电位比传统的听觉P30 0 诊断痴呆的敏感度明显提高 ,对于轻中度老年期痴呆的早期诊断有较大帮助价值。其中低概率非靶刺激诱发的P30 0 电位的异常应受到足够重视。Objective:To observe the changes of three tone paradigm P 300 in patients with mild senile dementia and explore the clinical application value of P 300 in the diagnosis of mild senile dementia.Methods:The traditional P 300 (2t P 300 ) and three tone paradigm P 300 (3t P 300 ) were performed in 34 patients with senile dementia, and the results were compared with each other.Results:The abnormality of 2t P 300 and 3t P 300 mainly showed prolongation of the latency,bad differential and uncertain wareforms.Eighteen of the 34 patients with dementia showed abnormal 2t P 300 .The total abnormality rate was 52.9%.The abnormal 2t P 300 was found in 9 out of 24 patients with mild dementia,7 out of 8 moderate dementia cases and in all of the 2 patients with severe dementia. Thirty patients underwent 3t P 300 detection, 24 of them showed abnormality. The total abnormality rate of 3t P 300 was 86.7%. Among the 30 patients, abnormality of 3t P 300 was found in 20 of the 24 mild dementia patients, and in all of the 6 patients with moderate dementia.Conclusions:Three tone paradigm auditory P 300 might have better sensitivity in the early diagnosis of mild and moderate senile dementia as compared with traditional auditory of P 300 . Enough attention should be emphasized on the abnormality of P 300 evoked by rare non target (r nt) stimuli. [

关 键 词：事件相关电位 P300 听觉 老年性痴呆 

分 类 号：R749.16[医药卫生—神经病学与精神病学]