喹诺酮类药物的质子化作用及互变异构现象与荧光特性的相关性研究  

Studies on Correlation between Protonation and Tautomerism and Luminescence Characteristics of Quinolone

作　　者：杜黎明[1] 晋卫军[2] 董川[2] 刘长松[2] 

机构地区：[1]山西师范大学分析测试中心,临汾041004 [2]山西大学化学系,太原030006

出　　处：《光谱学与光谱分析》2001年第4期518-520,共3页Spectroscopy and Spectral Analysis

基　　金：国家自然科学基金 (批准号 :2 98750 1 6);山西省自然科学基金 (批准号 :2 0 0 1 1 0 1 6)资助课题

摘　　要：研究了不同酸碱条件下 8种喹诺酮类药物的荧光特性。发现了在不同pH介质中喹诺酮类药物的荧光波长和荧光强度的变化规律 ,并对喹诺酮类药物质子化作用及互变异构现象与荧光性质的相关性进行了考察。确定了不同酸碱条件下的两种发光形体 ,进而对相应的变化机理进行了探讨。The fluorescence characteristics of 8 kinds of quinolone in different pH medium were studied.Rules of wavelength and intensity of the fluorescence in different pH medium were discovered.The correlation between the protonation,tautomerism and luminescence characteristics of quinolone are studied.It is found that in pH 6-8 or 2-4 there are two luminescence species.By this, the new view is respresented that the change of luminescence characteristics is arised from the protonation and toutomerism of quinolones in different pH medium and the material point of luminescence developed in equiliblium system of tautomerizm.Additionly,the correlation between the protonation,toutomerism and luminescence is futher discussed.

关 键 词：喹诺酮类药物 荧光光谱 互变异构现象 质子化作用 药物设计 相关性 抗菌药物 

分 类 号：R978.1[医药卫生—药品] R914.2[医药卫生—药学]