乳腺癌组织c-erbB-2癌基因产物蛋白表达及其临床意义  

Relationship of c-erbB-2 gene product expression and the clinical significance

作　　者：韩恩善[1] 马爱玲[1] 张建中[1] 秦景[1] 

机构地区：[1]宁夏医学院附属医院病理科,宁夏银川750004

出　　处：《宁夏医学杂志》2001年第7期387-388,共2页Ningxia Medical Journal

摘　　要：目的　探讨c-erbB - 2在乳腺癌表达中的意义。方法　采用免疫组化 (S -P法 )对 5 4例乳腺癌组织中c -erbB - 2进行检测 ,并结合临床资料及癌组织雌激素受体 (ER )、孕激素受体 (PR )水平进行分析。结果c-erbB - 2在乳腺癌组织中的阳性表达率为 5 5 .6 % ,c -erbB - 2表达与乳腺癌组织学类型无关 ,与ER、PR表达呈负相关 ,c-erbB - 2阳性率在乳腺癌伴淋巴结转移组为 73.3% ,无淋巴结转移组为 33.3% ,两组间存在显著性差异 (P <0 .0 5 )。结论　c-erbB -Objectives To study the relationship between the expression of c-erbB-2 and prognosis of breast cancer.Method54 of breast cancer were examined by immunohistochemistry technique(S-P method).Combining with the clinical information and ER、PR of the breast cancer were discussed.Result The positivity rate of c-erbB-2 expression in breast cancer were 55.6%,the positivity rate of c-erbB-2 expression in node-positive and in node-negative groups were 73.3% and 33.3% respectively(P <0.05). Conclusion The expression of c-erbB-2 is closely linked to lymphnode metastasis and prognosis of breast cancinoma and should be considered to a certain extent as index of malignant degree and prognosis.

关 键 词：乳腺肿瘤 C-ERBB-2 淋巴转移 基因表达 

分 类 号：R737.9[医药卫生—肿瘤]