补骨合剂对种植体—骨结合界面BMP含量变化的影响  

The Histomorphologic Study of the Effect of Bugu Capsule on the Osseointegration of Dental Implants

作　　者：李楠[1] 潘在兴[2] 王和鸣[1] 叶起清[2] 谢丹榕[2] 

机构地区：[1]福建中医学院骨伤系,福建福州350003 [2]福建省级机关医院口腔科

出　　处：《中国中医骨伤科杂志》2001年第4期17-19,共3页Chinese Journal of Traditional Medical Traumatology & Orthopedics

基　　金：福建省科委资助课题 编号 :96Z15 1

摘　　要：目的 :通过观察补骨合剂对口腔骨内种植体—骨结合界面骨形态发生蛋白含量的影响 ,初步探讨补骨合剂促进骨整合的作用机理 ,为补骨合剂促进口腔种植体骨整合提供客观的理论实验依据。方法 :成年杂种狗 2 0只 ,拔除左侧下颌第 2、3、4前磨牙 ,3个月后各植入钝钛种植体 3枚。随机分为实验组和对照组 ,实验组予补骨合剂灌胃 ,分别于术后 1、2、4、8、1 2周取出标本进行种植体—骨界面骨整合情况观察。结果 :实验组第 1周种植体 -骨界面骨形态发生蛋白 (BMP)平均灰度显著增高 (P<0 .0 1 ) ,较对照组提前约 1周。结论 :补骨合剂可以促进口腔骨内种植体骨整合。其可能机理 :促进 BMP的早期释放聚集 ,提高种植体—骨界面的BMP浓度。Objective:To investigate the mechanism of the effect of Bugu Capsule(BGC) on osseointegration and provide data for the practical use of BGC, by measuring related index of the influence of BGC on the dental implant osseointegration.Methods:A randomized, controlled experiment was conducted.20 adult dogs were divided two groups: experimented group and controlled group. Three left maxillofacial tooth were pulled out of all dogs, and were implanted with three titanium plast. The dogs of experimental group were ingested with BGC. The implanted maxillofacial part were sampled to observe the changes of implant-bone interface immedately 1,2,4,8,12 week after the surgery.Results:The level of BMP of experimental group is statistically significantly higher than that of controlled group the first week after surgery.Conclusion:BGC can promote the osseointegration of oral maxillofacial implants;The mechanism is to induce the release and congregation of BMP and increase the concentration increase the number an.

关 键 词：口腔骨内种植体 骨形态发生蛋白 实验研究 犬 义齿种植 补骨合剂 BMP 

分 类 号：R783.6[医药卫生—口腔医学]