原发性中枢神经系统淋巴瘤的伽玛刀治疗  

Treatment of Primary CNS Lymphoma by Gamma Knife

作　　者：董亚非[1,2,3] 潘力[1,2,3] 王滨江[1,2,3] 王恩敏[1,2,3] 张南[1,2,3] 蔡佩武[1,2,3] 戴嘉中[1,2,3] 

机构地区：[1]复旦大学附属华山医院 [2]伽玛医院神经外科,200233 [3]伽玛医院神经放射科,200233

出　　处：《中国临床神经科学》2001年第2期168-171,共4页Chinese Journal of Clinical Neurosciences

摘　　要：目的 :评估伽玛刀治疗原发性中枢神经系统淋巴瘤 (PCNSL)的疗效及探讨对其治疗方案的选择。方法 :3 6例经立体定向穿刺活检或手术病理证实为PCNSL的患者采用伽玛刀治疗 ,并对其临床资料、影像特征、治疗方法和随访结果作一回顾性分析。结果 :3 4例术后 1～ 3周临床症状均明显改善。肿瘤完全缓解 (CR) 3 0例 (83 3 %) ,部分缓解 (PR) 6例 (16 6%) ,卡氏评分迅速由术前的平均 5 0 %上升为平均 80 %,局部控制率为 10 0 %。结论 :伽玛刀是综合治疗本病的安全、有效方法之一 。Aim:To explore the therapeutic alternatives and evaluate the related clinical results for patients with primary central nervous system lymphoma (PCNSL) treated by gamma knife. Methods:36 cases of PCNSL, undergone stereotactic biopsy or craniotomy, and confirmed by pathologic examination, were treated by gamma knife radiosurgery. Those clinical materials, image feature, treatment methods and results of follow up were retrospectively reviewed. Results:Clinical symptoms and signs in 34 cases were markedly improved within 1～3 weeks after stereotactic radiosurgery. The lesions were CR in 30 patients (83 3%), PR in 6 (16 6%). Kamofsky scale was also improved from 50% preoperatively to 80% postoperatively. Local control rate was 100%. Conclusion:It is one of the safe and effective methods by using gamma knife in multimodality treatment of PCNSL. Stereotactic biopsy plus gamma knife should be regarded as an initial treatment of choice.

关 键 词：中枢神经系统淋巴瘤 立体定向放射手术 放射治疗 PCNSL 伽玛刀 

分 类 号：R749.41[医药卫生—神经病学与精神病学] R730.55[医药卫生—临床医学]