正常及先天性色觉异常者颜色视觉诱发电位的研究  

Study on chromatic visual evoked potential (VEP) of normal people and congenital color vision deficient.

作　　者：刘虹[1] 郭静秋[1] 

机构地区：[1]北京大学第一医院小儿眼科

出　　处：《中国斜视与小儿眼科杂志》2001年第2期61-66,共6页Chinese Journal of Strabismus & Pediatric Ophthalmology

摘　　要：目的　了解颜色刺激正常人和色觉异常者不同记录部位的VEP表现 ,作临床功能判断和色觉机制分析的参考。方法　通过实验用计算机软件控制亮度和颜色因素 ,用黑 白棋盘格和等亮度的红 白、绿 白及红 绿颜色棋盘格作为刺激模式 ,记录一组正常人及色觉异常者的瞬态诱发电位。结果　 ( 1 )正常人在红 白、绿 白及红 绿刺激下 ,1 0导联P1波振幅低 ,在红 白、绿 白刺激下 ,1 5导联P1波潜伏期长 ,结果比较具有统计学意义。 ( 2 )正常人在上述四种刺激条件下P1波潜伏期按时间长短顺序 ,红 白 <黑 白 <红 绿 <绿 白 ,潜伏期之间的比较具高度显著性 ;P1波振幅的高低是黑 白 >红 白、红 绿、绿 白 ,差异有显著性 ,但颜色刺激之间振幅的比较无差异。 ( 3)色觉异常组在四种刺激每件下P1波潜伏期长短及振幅的高低之间无差异 ,但黑 白刺激潜伏期最短。红绿色盲及绿色盲 ,对绿 白刺激无反应 ,对红 白及红 绿有反应 ,但振幅较正常人显著降低。 ( 4)正常组与色觉异常组P1波的比较 ,潜伏期无差异 ,振幅在黑 白刺激下无差异 ,在颜色刺激下 ,差异有显著性。结论　 ( 1 )颜色视觉诱发电位客观地检查先天性色觉异常是可行的 ,对红绿色盲和绿色盲尤为敏感。 ( 2 )在视中枢内可能有一个相对主要的颜色区域。 ( 3)Objective This sutdy is to present the different color visual evoked potential (VEP) waves between normal and color vision deficient. The aim is to serve as criterion evaluating the vision function and analyzing color mechanism. Method Four kinds of reversal checkerboard patterns are simulated by the compute software technology as stimuli, including black white, isoluminant red white, green white, red green chromatic checkerboards. The transient VEP were measured in normal people and color vision deficient. Results (1) In normal people group the P 1 latencies of 15 channel which were elicited with red white, green white checkerboard were longer, The P 1 amplitudes of 10 channel which were elicited with chromatic checkerboards were lower. (2) The P 1 latencies in four conditions were obtained and in terms of the length of latencies, the ordinal of P 1 latencies is as follows: red white <black white <red green <green white. There were very significant differences among the four latencies. The P 1 amplitudes elicited with the black white were higher than those with chromatic ones. But, among the P 1 amplitudes elicited with chromatic checkerboards there were no difference. (3) In color vision deficient group there were no significant differences in the P 1 latencies and amplitudes elicited with the four stimuli. But P 1 latencies elicited with black white stimulus was shortest. Red green blindness and deuteranopia had no response to green stimulus but did to red or red green stimulus. (4) Between the two groups there were no differences in the P 1 latencise, but the P 1 amplitude of abnormal group elicited with the chromatic stimuli were obviously lower. Conclusion (1) it is feasible to use chromatic VEP for examining congenital color vision deficient, especially for red green blindness and deuteranopia. (2) There are relatively main chromatic processing field in the visual cortex center. (3) The color and bringhtness may be dealt with in the same visual system, the parvocellular pathway. (

关 键 词：色觉 图形视觉诱发电位 VEP 

分 类 号：R770.43[医药卫生—眼科]