低水平铅暴露对不同脑发育期大鼠学习记忆能力的影响  

Effects of low level lead exposure on learning and memory of rats in different stages of brain development

作　　者：黄琼[1] 许月初[1] 王身笏[1] 蒋卓勤[1] 

机构地区：[1]中山医科大学公共卫生学院医学营养系,510080

出　　处：《卫生毒理学杂志》2001年第3期149-151,共3页Journal of Health Toxicology

摘　　要：目的　通过建立低水平铅暴露模型 ,研究低水平铅暴露对不同脑发育期大鼠学习记忆能力的影响。方法　将大鼠孕 14d至仔鼠出生 2 1d分成不同时期对其进行低水平铅暴露 ,观察仔鼠生长发育情况 ,仔鼠出生 2 1d开始进行跳台和水迷宫实验。结果　除出生早期组仔鼠 2 8d时体重低于其余 3组 ,4 0d时体重低于对照和孕晚期组外 ,其余各组各期体重与对照组比较无明显差异 ;水迷宫实验 :对照组仔鼠第 2和第 4天潜伏期较染毒组缩短5 0 %以上 ,第 2天错误数平均为 4 2 5次 ,低于染毒组 ;跳台实验 :对照组第 1天和第 2天错误数较出生早期少 ,第 2天潜伏期平均为 2 2 3min ,较染毒组潜伏期长。结论　低水平铅暴露对大鼠脑发育各期学习记忆能力均有损伤作用 ,但大鼠出生至出生 10d可能是铅对其神经行为损害的高敏期。Objective The effects of low level lead exposure on learning and memory of rats in different stages of brain development were investigated.Methods From the 14th day of gestation to the 21th day after birth, the rats were given lead exposure in different stages. The pups' development and growth conditions were researched. From the 21th day after birth, Water-maze test and Step-down test were carried out.Results The pups' weights of group C at the 28th day and the 40th day after birth were lower than those of other groups. Water-maze test:the incubation periods of the second and the fourth day of control group were decreased more than 50 percent, and the error times of the second day were fewer than those of other groups ( P<0.05 ). Step-down test:on the second day, the error times of control group were significantly fewer than those of group C, and the incubation period was significantly shorter than that of other groups ( P<0.05) . Conclusion These results indicated that low level lead exposure during different stages of brain developmetn of rats could damage their learning and memory, but the rats 1-10 days old seemed more sensitive to lead neurotoxicity.

关 键 词：铅 学习 记忆 大鼠 毒理学 

分 类 号：R995[医药卫生—毒理学] R992[医药卫生—药学]