白血病患者对弓形虫的易感性及其临床意义  

STUDIES ON SUSCEPTIBILITY OF LEUKEMIA PATIENTS TO INFECTION OF TOXOPLASMA GONDII AND ITS CLINICAL VALUE

作　　者：程玉芝[1] 李振娥[1] 董中霞[1] 李凤英[1] 

机构地区：[1]济宁医学院附属医院血液科,山东济宁272029

出　　处：《中国寄生虫病防治杂志》2001年第3期188-189,共2页Chinese Journal of Parasitic Disease Control

摘　　要：目的　探讨白血病患者对弓形虫的易感性及并发弓形虫感染后 ,经抗弓形虫治疗的临床意义。　方法　应用PCR/ DNA探针检测技术 ,对白血病患者及对照组人群进行弓形虫病原 DNA检测。　结果　白血病患者中弓形虫 DNA检测阳性率为 15 .8% ,而同期住院的非白血病病人的阳性率为 3.3% ,差异非常显著。在白血病病例组中 ,以复发难治性患者的阳性率最高 ,显著高于其它组。白血病病人弓形虫检测组 ,在对原发病系统化疗的基础上 ,另加用抗弓形虫药物 ,治疗组的缓解率均比未治疗组为高 ,尤其是对弓形虫阳性的慢性白血病病例和复发难治病例 ,可进一步提高其缓解率。结论　白血病病人对弓形虫易感 ,在白血病病例组中 ,以复发难治性患者的阳性率最高 ,并发弓形虫感染的病人另加用抗弓形虫药物治疗后 ,可提高其缓解率。Objective To approach susceptibility of leukemia patient to Toxoplasma gondii infection and its clinical value after treatment with anti-toxoplasma medicine. Methods PCR/DNA probe was used to detect toxoplasma DNA in leukemia patients and controls. Results The infection rate of T. gondii was 15.1% in leukemia patients, but 3.3% in non-leukemia patients, and there was a significant difference between them(χ2=11.05, P<0.005). Among different groups of leukemia patients, the highest infection rate is in refractory cases (χ2=8.99,P<0.05). The patients with infection of T. gondii were treated with anti-toxoplasma medicine besides treatment for original disease and the remission rate was increased. Conclusion The leukemia patients are susceptible to T. gondii infection. The highest infection rate is in refractory cases. The remission rate increased in patients treated with anti-toxoplasma medicine.

关 键 词：白血病 弓形虫 易感性 治疗 

分 类 号：R733.705[医药卫生—肿瘤]