血清转化生长因子-α的测定对肝硬化及其恶变的价值  

SIGNIFICANCE OF TGF-α IN THE SERUM OF PATIENTS WITH MALIGNANT CHANGE CIRRHOSIS

作　　者：李根武[1] 伍灵达[1] 

机构地区：[1]广东医学院附属医院消化内科,湛江524001

出　　处：《中国现代医学杂志》2001年第7期47-47,53,共2页China Journal of Modern Medicine

摘　　要：目的 :了解肝硬化、肝硬化并肝癌患者血清TGF -α的变化 ,研究TGF -α检测对肝硬化恶变的诊断价值。方法 :放免法检测肝硬化代偿期 2 2例、肝硬化失代偿期 17例、肝硬化并肝癌 18例的血清TGF -α水平。结果 :血清TGF -α水平在肝硬化代偿期与正常对照组无差别 (P >0 .0 5 ) ,肝硬化失代偿期者明显高于代偿期者 (P <0 .0 5 ) ,肝硬化并肝癌者明显高于肝硬化失代偿期者 (P <0 .0 1)。结论 :血清TGFObjective:to investigate the alteration of TGF-α in the serum of the patients with cirrhosis、Liver cancer accompanied with cirrhosis.Methods:Using radioimmunotogical method to test TGF-α in the serum of 22 patients of cirrhosis without ascites、17 patients of cirrhosis with ascites、18 patients of cirrhosis accompanied with primary liver cancer.Results:The contents of TGF-α in the serum did not differ between two groups of cirrhosis with ascites and normal persons (P>0.05).The contants of TGF-α in the serum of patients with cirrhosis and of patients with the latter alone was significantly higher than those of patients cirrhosis with ascites(P<0.05).The contents of TGF-α in the serum of patients with cirrhosis accompanied with liver cancer and of patients with the latter alone was significantly higher than those of patients with cirrhosis with ascites(P<0.01).Conclusions:The determination of the serum TGF-α is a valuable market of malignant change cirrhosis.

关 键 词：TGF-Α 肝硬化 原发性肝细胞癌 CT 

分 类 号：R575.2[医药卫生—消化系统]