血管生成与p53、c-erb B-2癌基因蛋白在乳腺非典型增生及癌变过程中的相关性  

RELATIONSHIP BETWEEN ANGIOGENESIS AND p53, c-erb B-2 ONCOGENE PROTEIN IN MALIGNANT AND PRECANCEROUS LESIONS IN BREAST

作　　者：刘胜春[1] 吴凯南[1] 厉红元[1] 张震寰[1] 

机构地区：[1]重庆医科大学附属第一医院普外科,重庆400016

出　　处：《中国普外基础与临床杂志》2001年第5期304-306,共3页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的　探讨 p53及c erbB 2癌基因蛋白在乳腺非典型增生及癌变组织中的表达及其在非典型增生及癌变过程中与血管生成的关系。方法　对 1 0 3例正常乳腺、乳腺非典型增生及乳腺癌组织的 p53及c erbB 2癌基因蛋白及第 8因子相关抗原FⅧ RA进行免疫组化染色。对微血管内皮细胞面积 (MEA)进行CIAS定量测定 ,并分析 p53及c erbB 2与MEA的相关性。结果　在轻度非典型增生组织中 ,p53癌基因蛋白阳性表达组MEA( 4 1 94.89±498.5998)高于阴性组 ( 32 1 6 .94±80 3.9394,t =2 .30 2 4,P<0 .0 5)。中重度非典型增生组织中 ,p53阳性组MEA ( 4 52 5.82 ±1 36 0 .82 77)高于阴性组 ( 356 4 .6 1± 6 87.0 6 4 6 ,t=2 .1 794,P<0 .0 5)。c erbB 2与MEA无相关性 (P>0 .0 5)。结论　在乳腺非典型增生及癌变过程中 ,p53癌基因蛋白表达与血管生成具有明显相关性。Objective To investigate the association between p53, c erb B 2 oncogene protein and angiogenesis in breast carcinoma and breast with atypical hyperplasia. Methods Immunohistochemical reaction of p53, c erb B 2 oncogene protein was evaluated in 103 benign and malignant lesion breast paraffin embedded specimens. The microvessel endothelial area (MEA) was quantitated by computer image analysis system (CIAS), which was immunohistochemically stained by FⅧ RA. The relationships between p53, c erb B 2 and MEA were analyzed. Results The MEA of p53 oncogene protein positive expression in mild atypical hyperplasia breast lesion was significantly higher than that in p53 negative ( t = 2.302 4, P <0.05). The MEA of p53 oncogene protein positive expression in severe atypical hyperplasia was higher than that in p53 negative ( t =2.179 4, P <0.05). Moreover, no significant association between c erb B 2 oncogene protein and MEA was observed. Conclusion p53 oncogene mutant,protein expression is significantly related to angiogenesis.

关 键 词：血管生成 P53基因蛋白 C-ERBB-2基因蛋白 乳腺非典型增生 乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]