奥美拉唑与醋氨已酸锌剂联合应用对提高消化性溶疡愈合质量的影响  

The Effect of Omeprazoleand Zinc Acexamate on the Healing Quality in the Treatment of Active Peptic Ulcers

作　　者：胡伏莲[1] 高文[2] 张希全[1] 钱大可 袁爱力[3] 

机构地区：[1]北京大学第一临床医学院消化内科,北京100034 [2]浙江大学医学院附属第二医院,杭州310006 [3]第一军医大学南方医院,广州510515

出　　处：《中国临床药理学杂志》2001年第4期257-260,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：目的：通过比较奥美拉唑＋醋氨己酸锌与奥美拉唑＋安慰剂治疗胃及十二指肠溃疡的溃疡愈合率和Ｓ２获得率来评价醋氨己酸锌对提高溃疡愈合质量的作用。方法：本研究采用双盲单模拟的多中心临床研究，将内镜证实的胃溃疡６１例，十二指肠溃疡７５例随机分成试验组（奥美拉唑＋醋氨己酸锌）和对照组（奥美拉唑＋安慰剂），剂量为奥美拉唑２０ｍｇ，ｑｄ，醋氨基酸锌３００ｍｇ，ｔｉｄ；疗程：十二指肠溃疡治疗４周；胃溃疡６周。结果：溃疡愈合率：胃溃疡试验组和对照组分别为 ９３．３％（４２／４５）和 ９３．８％（ １５／１６）；十二指肠溃疡为 ８９．１％（４１／４６）和 ８２．ｌ％（２４／２９）；无论胃溃疡或十二指肠溃疡两组对照均无明显差异（Ｐ＞０．０５）；Ｓ２获得率：胃溃疡试验组与对照组分别为６１．９％（２６／４２）和２６．７％（４／１５）；十二指肠溃疡为５８．５％（２４／４２）和２９．２％（７／２４）；无论胃溃疡和十二指肠溃疡试验组的Ｓ２获得率均明显高于对照组（Ｐ＜０．０５）。结论醋氨己酸锌能明显提高胃及十二指肠溃疡的Ｓ２获得率，研究结果表明醋氨己酸锌在提高溃疡的愈合质量中起重要作用。OBJECTIVE: To evaluate the effect of zinc acexamate on the quality of ulcer healing in a trial comparing the healing rates and the stage S2 achievement rates of therapy with omeprazole plus zinc acexamate or placebo in treatment of gastric and duodenal ulcer patients. METHODS: One hundred and thirty-six patients, 61 with gastric ulcer (GU) and 75 with duodenal ulcer (DU) proven by endoscopy, were randomized to test groups (omeprazole 20mg qd + zinc acexamate 300mg tid for 6 weeks in GU and 4 weeks in DU) and control groups (omeprazole 20mg qd + placebo for 6 weeks in GU and 4 weeks in DU) in a multicenter double-blind single-dummy clinical trial. RESULTS: The healing rates of GU were 93.3% (42/45) and 93.8% (15/16) in test and control group, respectively; while those of DU were 89.1 % (41/46) and 82.1 % (24/29). The healing rates of the two groups were similar in both GU and DU (P>0.05). The stage of S2 achievement rates of GU were 61 .9% (26/42) and 26.7% (4/15) in test and control group, respectively; while those of DU were 58.5% (24/41) and 29.2% (7/24). In either GU or DU patients the stage S2 achievement rate of test group was significantly higher than that of control groups (P<0.05). CONCLUSION: Zinc acexamate distinctly increased the stage S2 achievement rates in treatment of gastric and duodenal ulcers. This study has shown that zinc acexamate may play an important role in improving the healing quality of peptic ulcers.

关 键 词：醋氨己酸锌 奥美拉唑 胃溃疡 十二指肠溃疡 药物联合治疗 

分 类 号：R573.1[医药卫生—消化系统]