重症肌无力合并癫痫的发病机制探讨  

Pathogenesis of Myasthenia Gravis Complicated with Epilepsy

作　　者：方丽波[1] 刘广志[2] 许贤豪[1] 陈伟群[2] 

机构地区：[1]首都医科大学附属北京复兴医院神经内科 [2]北京医院神经内科

出　　处：《首都医科大学学报》2001年第3期239-240,共2页Journal of Capital Medical University

摘　　要：为探讨重症肌无力 (MG)合并癫痫 (EPI)的发病机制 ,对 1 5例合并癫痫的MG患者的临床表现及实验结果进行分析。发现 1 5例患者在MG症状加重时出现癫痫发作 ,在MG症状减轻时发作缓解。MG合并EPI组的脑脊液IgG及脑脊液 2 4hIgG合成率高于MG不合并EPI组及对照组。间接提示癫痫的发作与中枢神经系统内乙酰胆碱受体抗体 (AchRab)的异常合成有关。This study explored the pathogenesis of myasthenia gravis(MG) complicated wity epilepsy. The study analyzed the clinical manifestation and experimental results of 15 MG patients complicated wity epilepsy. The attack of epilepsy occurred with the aggravation of the clinical symptom of MG and relived with the improvement of MG respectively. The levels of CSF IgG and the CSF IgG 24 h synthetic rate in the group with MG complicated with epilepsy (MG+EPI) were higher than those in the other two groups, the group of MG without EPI (MG-EPI) and the control group. The attack of epilepsy is related with the abnormally synthetic acetylcholine receptor antibody (AchRab) in the central nervous system.

关 键 词：重症肌无力 癫痫 发病机制 合并症 诊断 治疗 

分 类 号：R746.1[医药卫生—神经病学与精神病学] R742.1[医药卫生—临床医学]