膀胱癌患者性激素和T细胞亚群关系的研究  

Study of Correlation of Sex Hormone and T Cell Subpopulations in Bladder Cancer

作　　者：米华[1] 甘俊常[1] 刘天长[1] 李盛宽[1] 黄伟华[1] 

机构地区：[1]广西医科大学第一附属医院泌尿外科,南宁530021

出　　处：《四川肿瘤防治》2001年第3期143-145,共3页Sichuan Journal of Cancer Control

摘　　要：目的 :探讨膀胱患者的性激素和T细胞亚群的关系。方法 :对29例男性膀胱癌患者和25例正常男性的血清性激素水平及T细胞亚群进行测定。结果 :膀胱癌患者血清中睾酮(T)升高和雌二醇(E2)下降 ,T/E2升高 ;外周血T淋巴细胞亚群CD3、CD4和CD4/CD8下降 ,而CD8升高 ,T/E2 和CD4/CD8 呈直线负相关。结论 :性激素比例失调、细胞免疫功能低下可能与膀胱癌的发生、发展有关。Objective:To study the correlation between sex hormone and the status of T cell subpoputations in bladder cancer.Methods: Serum testosterone(T),estradiol(E 2) and T cell subpopulations(CD 3?CD 4?CD 8) were determined in 29 patients with bladder cancer,and as well as in 25 healthy men as the control group.Results:In bladder cancer patients,their T and T/E 2 were higher and E 2 was lower than those of in control group cases,and also the proportion of CD 3?CD 4 T-cell subsets and the ratio of CD 4/CD 8 were lower,but CD 8 T-cell subsets was higher than those of in normal controls.The relationship bewteen T/E 2 and CD 4/CD 8 was negative linear correlation.Conclusions:It is likely that the carcinogenesis and the development of bladder cancer is correlated to the imbalance of sex hormone and hypofunction of cellular immunity.

关 键 词：膀胱癌 性激素 T细胞亚群 

分 类 号：R737.14[医药卫生—肿瘤]