胃癌的家族聚集性研究  

Study on Familial Aggregation in the Occurrence of Gastric Cancer

作　　者：覃玉[1] 徐耀初[1] 沈洪兵[1] 周玲[1] 李建树[1] 喻荣彬[1] 钮菊英[1] 郭剑涛[2] 徐爱玲[2] 王志华[2] 贺兴[2] 胡旭 徐天亮 开海涛 

机构地区：[1]南京医科大学流行病学教研室 [2]江苏省金坛市卫生防疫站,江苏金坛213200 [3]江苏省淮安市(现楚州区)卫生防疫站,江苏淮安223200

出　　处：《中国肿瘤》2001年第9期503-505,共3页China Cancer

摘　　要：本文采用遗传流行病学病例对照研究方法 ,探讨遗传因素在胃癌病因中所起的作用 ,并研究胃癌的家族聚集性。结果病例组有胃癌家族史的比例 (22.53% )显著高于对照组 (10.79% ) ,病例组一级亲属患胃癌的比例 (3.21% )高于对照组(1.44% ,OR=2.27,95%CI1.38～3.73)。用(p+q)n 模型拟合结果家族中实际病例数的分布高于二项分布的概率范围 ,经频数分布拟合优度的检验 ,P<0.01,说明胃癌在家族中并非按机会均等的概率分布 ,而是呈现明显的家族聚集现象 ,胃癌家族史是胃癌发生的危险因素。We analyzed Familial Aggregation in the occurrence of gastric cancer (GC) on the basis of a population_based case_control study conducted and synthetically evaluated the role of genetic factor. There were 182 proband ancestries and 241 control ancestries. The result showed that the positive family history of GC in probands (22.53%) was higher than that in controls (10.79%,P<0.01). The GC prevalence in first_degree relatives of probands (3.21%) was higher than that in controls (1.44%,OR=2.27, 95%CI1.38～3.73). The distribution of GC in the predigrees of probands was significantly different from that in controls. It is showed that there is significant familial aggregation in the occurrence of GC in the first_degree relatives of probands, and the GC family history is one of the important risk factors.

关 键 词：遗传 家族聚集性 胃癌 

分 类 号：R735.202[医药卫生—肿瘤]