胃癌术前应用“双弹头”免疫导向治疗的临床研究  

Clinical study of immunoguided therapy with antibody-targeted radio-chemotherapy on preoperative gastric carcinoma

作　　者：郭文斌[1] 姜清华[1] 梁怀祝[1] 高众[1] 

机构地区：[1]大连市中心医院普外2科,辽宁116033

出　　处：《中国肿瘤临床与康复》2001年第4期41-42,共2页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的　探讨应用“双弹头”免疫导向技术术前治疗胃癌的临床效果。方法　应用13 1Ⅰ - 3H11对 2 4例胃癌病人行内镜下癌灶多点注射 ,48小时后采用ADM - 3H11对上述患者行选择性动脉区域局部灌注 ;选择 6例胃癌病人采用FAM方案化疗作为对照组。并对术后标本进行观察、研究。结果　 87.5 % (2 1/2 4)病理出现癌细胞核固缩、碎裂、细胞浆凝固、细胞间质出现炎细胞浸润 ;这些变化多以中度为主 ,重度及无变化较少。结论　作为胃癌的综合治疗方法 ,术前胃癌局部注射13 1Ⅰ - 3H11,选择性动脉注入ADM - 3H11具有临床应用前景。Objective To investigate clinical effect of drugs of dual-warhead missile made of 131 Ⅰ-3H11 and ADM-3H11 on preoperative carcinoma.Methods 24 patients with gastric carcinoma received endoscopic intra-tumor injection of 131 Ⅰ-3H11 firstly and selective intra-arterial infusion of ADM-3H11 48 hours later.6 gastric carcinoma patients with routine regimen of FAM were as controls. Postoperative specimens were histologically analysed.Results Under light microscope,karyopyknosis,karyorrhexis,coagulation and necrosis of cytoplasm and invasion of lymphocyte were found.Most of these changes were in grade Ⅱ.Conclusion Preoperative endoscopic intra-tumor injection of 131 Ⅰ-3H11 plus selective intra-arterial infusion of ADM-3H11 can cause evident histological and cellular changes,which is recommended as one of integrative therapy to gastric cancer.

关 键 词：单克隆抗体 免疫导向治疗 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]