云锡等厂矿粉尘中七种化学成分诱发金仓鼠肺癌实验研究  

Experimental Studies of Inducing Lung Cancer on Hamsters by Seven Chemical Elements in Yunnan Tin Mine Dust

作　　者：黄润[1] 张志杰[1] 杨昆胜[1] 黄翠轩[1] 章宗籍[1] 毛玉明[2] 阮永华[1] 王芳[1] 田昆[2] 

机构地区：[1]昆明医学院病理教研室 [2]昆明医学院劳卫与职业病教研室

出　　处：《昆明医学院学报》1991年第3期18-22,共5页Journal of Kunming Medical College

基　　金：中国科学院科学基金

摘　　要：云锡矿工肺癌高发,为探明矿尘中放射性化学成分的致癌性,选择7种与致突变及致癌有关的非放射性无机化学物质(代号CM_2,含砷、铅、铁、铬、镍、镉、铍)进行Ames试验及金仓鼠诱癌实验。结果如下:CM_2Ames试验阳性、CM_2金仓鼠诱癌实验阳性。27只有效动物中6只发生了肺癌及癌前病变,发生率22.2％。对照组无肿瘤发生。结果表明,CM_2对金仓鼠有致癌作用,为国内外首次报道。There is a high incidence of Lung cancer among the miners of Yunnan Tin Mine.In or- der to study the carcinogenicity of chemical elements with none radioactive in the mine pow- der,a mixture of seven non-radioactive,inorganic chemical elements(CM_2:As,Pb,Fe, Cr,Ni,Cd and Be)relating to mutagenicity and tumorgenesis were chosen for Ames test and carinoma inducing experiments in hamsters.The results are as follows:1 Ames test of CM_2is positive.2 The lung cancer inducing experiment of CM_2on hamsters is successful.Lung cancer and precancerous lesions develop in 6 of 27 effective animals, the incidence is 22.2%.No tu- mor was found in the control group.The results show that CM_2is related to the lung cancer formation of hamsters,tihs is reported for the first time.

关 键 词：肺肿瘤 化学物质 致癌性 

分 类 号：R734.202[医药卫生—肿瘤]