普罗布考对脑梗塞患者一氧化氮调节作用的临床研究  

The clinical study of probucol in cerebral infarction patients on NO regulating role

作　　者：杨柳竹 张永军[1] 宁越峰 刘志敏[1] 许树旭[1] 高忠显 孙国权 

机构地区：[1]北京军区第266医院,河北承德067000 [2]河北省承德市普宁制药厂,河北承德067000

出　　处：《河北医学》2001年第8期695-697,共3页Hebei Medicine

摘　　要：目的 :探讨普罗布考对脑梗塞患者一氧化氮 (NO)的调节作用。方法 :用Green改良法检测脑梗塞患者血清服药前和服药后的NO含量。结果 :脑梗塞患者血清NO水平明显高于正常值 (P <0 .0 5) ,服用普罗布考治疗 4周后患者NO水平恢复正常 ,临床疗效较常规治疗组明显提高 (P <0 .0 5)。结论 :普罗布考可调节脑梗塞患者NO水平、减轻缺血性损伤、促进神经功能恢复。Objective: To explore Probucol played a regulating role in cerebral infarction patients by NO Methods: Using Green improving way, NO serum level of patients were detected,with taking drugs before and after. Results: NO level of patients were obviously higher than normal (P<0.05). But after taking Probucol 4 weeks,It restored. The therapeutic effect were higher than normal treatment group(P<0.05). Conclusion: Probucol can regulated NO level of cerebral infarction patients, decreased ischemia injury, and accelerated nervous function recovery.

关 键 词：普罗布考 脑梗塞 一氧化氮 NO 调节作用 神经功能恢复 

分 类 号：R743.33[医药卫生—神经病学与精神病学]