高血压病、冠心病与β_3肾上腺素能受体基因Trp64Arg突变的相关性研究  

Relationship between β_3 adrenergic receptor gene Trp64Arg mutation and hypertension and coronary heart disease

作　　者：王明琴[1] 徐文玲[1] 曲云东[1] 崔丽芳[1] 

机构地区：[1]济南铁路中心医院干部保健科,山东济南250001

出　　处：《铁道医学》2001年第4期225-227,共3页Railway Medical Journal

基　　金：济南铁路局自然科学基金资助课题 (2 0 0 0 ) 4号 44 (2 )

摘　　要：目的　研究 β3 肾上腺素能受体 (β3 ADR )基因Trp64Arg突变频率及其与高血压病、冠心病的关系。方法　对正常对照组 12 0人、高血压病组 2 15例、冠心病组 2 19例 ,进行血糖、血脂、身高、体重、血压、心电图及 β3 ADR基因Trp64Arg检测 ,判断基因型。结果　对照组 β3 ADR基因Trp64Arg突变率为 16.67% ,高血压组为 17.91% ,冠心病组为 17.81% ,各组间比较无差异性。结论　β3 ADR基因Trp64Arg突变与高血压病、冠心病的发病无关 。Objective To find out the relationship between β 3adrenergic receptor (ADR) gene Trp64Arg mutation and hypertension and coronary heart disease.Methods Body mass index (BMI),blood glucose,blood pressure and electrocardiogram,and the mutation of the β 3ADR gene Trp64Arg were determined(control group120,hypertension 215,coronary heart disease 219).Results Mutation frequency was 16.67% in control group,17.91% in hypertension group and 17.81% in coronary heart disease group.There was no difference of the rates of β 3 ADR gene Trp64Arg mutation among the three groups.Conclusion There is no relationship between β 3 ADR gene Trp64Arg mutation and onset of hypertension and coronary heart disease.The mutation of β 3ADR gene Trp64Arg may not play a major role in the onset of hypertension and coronary heart disease.

关 键 词：高血压 Β3肾上腺素能受体 基因突变 冠心病 

分 类 号：R544.1[医药卫生—心血管疾病]