贲门癌术后反流性食管炎66例的药物治疗  

Medicine treatment for 66 cases with reflux esophagitis resulting from postoperative cardiac carcinoma

作　　者：陈国祥[1] 金雪熙[1] 徐幼龙[1] 除全兴[1] 张世统[1] 冯涛[1] 杨大明[1] 

机构地区：[1]上海市长宁区中心医院肿瘤科,上海200336

出　　处：《中国癌症杂志》2001年第4期333-334,337,共3页China Oncology

摘　　要：目的 :探讨治疗贲门癌术后反流性食管炎的药物选择及临床疗效的评估。方法 :对 6 6例贲门癌术后反流性食管炎首先口服雷尼替丁 15 0mg/次 ,2次 /d ,吗丁啉 10— 2 0mg/次 ,3次 /d(或西沙必利 5— 10mg/次 ,3次 /d) ,硫铝糖 1g/次 ,3次 /d。无效者改用奥美拉唑 ,剂量为 2 0— 40mg/次 ,1次 /d。结果 :联合治疗后有 5 1 5 % (34/6 6 )的患者症状消失或明显缓解 ;无效者改用奥美拉唑治疗后有 93 8% (30 /32 )的患者症状消失或明显缓解。结论 :在选择治疗贲门癌术后反流性食管炎的药物时 ,首先可选用雷尼替丁、吗丁啉 (或西沙必利 )、硫糖铝联合治疗 ,无效者改用奥美拉唑 ,可增加贲门癌术后反流性食管炎的疗效。Purpose:To observe medicine in the treatment of reflux esophagitis resulting from postoperative cardiac carcinoma. Methods:66 patients with reflux esophagitis resulging from postoperative cardiac carcinoma firstly were treated with ranitidine-motilium/cisapridc-sucralfatc combined regimen and the doses were 150 mg(bid),10-20 mg(tid),5-10 mg(tid),1 g(tid),respectively. The patients with no efficacy with combined regimen were treated ulteriorly with omeprazole, the dose was 20-40 mg(qd). Results:The clinical disappearing or improvement was attained by 51.6%(34/66) in patients treated with combined regimen, and by 93.8%(30/32) in patients (with no efficacy with combined ergimen) treated with omeprazole. Conclusions:Omeprazole could be efficacious for patients with reflux esophagitis resulting from postoperative cardiac carcinoma with no efficacy with ranitidinc-motilium/cisapridc-ulccrlmin combined regimen. Omeprazole as preferred therapy for reflux esophagitis resulting from postoperative cardiac carcinoma should be tested.

关 键 词：贲门癌 反流性食管炎 药物治疗 手术后 

分 类 号：R735.2[医药卫生—肿瘤] R571[医药卫生—临床医学]