癌基因CD_(44s)在胰腺癌组织中的表达及临床意义  

Expression of CD_(44) in pancreatic carcinoma and its clinical significance

作　　者：李明皓[1] 韩恩善[2] 安永[3] 秦憬[2] 李国富[2] 

机构地区：[1]宁夏医学院附属医院肝胆外科,银川市750004 [2]宁夏医学院附属医院病理科,银川市750004 [3]重庆西南医院

出　　处：《中华肝胆外科杂志》2001年第9期552-554,共3页Chinese Journal of Hepatobiliary Surgery

摘　　要：目的探讨癌基因 CD_(44s)表达与人胰腺癌转移、分化、浸润的关系。方法应用免疫组化(S-P 法)技术检测人胰腺癌组织中 CD_(44s)的表达。结果人胰腺癌组织中 CD_(44s)表达在淋巴结无转移及高分化腺癌中明显地高于淋巴结有转移及低分化腺癌。结论 CD_(44s) 可做为胰腺癌分化、转移、浸润的潜在指标之一。Objective To explore the relation of CD_(44s) expression to metastasis,differentiation and invasion of pancreatic carcinoma.Methods The expression of CD_(44s) in tissues of pancreatic carci- noma was detected with immunohistochemistry.Results The expression of CD_(44s) in human pancreatic carcinoma was significantly higher in those patients with lymph node metastasis and lowly differentia- ted adenocarcinoma.Conclusions CD_(44s) can be used as one of the markers for judging the metatasis, differentiation and invasion of pancreatic carcinoma.

关 键 词：CD44S 胰腺肿瘤 肿瘤转移 基因表达 肿瘤分化 细胞粘附分子1 肿瘤侵润 

分 类 号：R735.9[医药卫生—肿瘤]