ABMT与APBSCT治疗白血病和淋巴瘤的初步效果  

A CLINICAL ANALYSIS OF AUTOLOGOUS BONE MARROW TRANSPLANTATION AND AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION IN PATIENTS WITH ACUTE LEUKEMIA OR MALIGNANT LYMPHOMA

作　　者：赵洪国[1] 孟繁军[1] 刘金兰[1] 刘竹珍[1] 李光伦[1] 崔中光[1] 

机构地区：[1]青岛大学医学院附属医院血液科,青岛266003

出　　处：《青岛大学医学院学报》2001年第4期279-281,共3页Acta Academiae Medicinae Qingdao Universitatis

基　　金：青岛市自然科学基金资助项目 ( 1999 6 2 )

摘　　要：目的　探讨自体骨髓移植 (ABMT)、自体造血干细胞移植 (APBSCT)治疗急性白血病和恶性淋巴瘤的效果。②方法　应用ABMT和APBSCT治疗 6例急性白血病和 4例恶性淋巴瘤 ,全部病人随访 1.0～ 4.3年。③结果　 10例病人移植后全部造血功能重建 ,无 1例病人发生移植相关死亡 ,ABMT和APBSCT后中性粒细胞恢复至>0 .5× 10 9/L时间分别为 12 (9～ 15 )和 10 (9～ 12 )d ,血小板恢复至 >2 0× 10 9/L时间分别为 16 (13～ 2 2 )和 13(8～ 41)d ;移植后无病存活期为 1.4(0 .3～ 4.3)年 ,4例病人至今已无病生存 1.3,1.4,3.8,4.3年 ,6例病人在移植后 0 .3～3.3年复发。④结论　ABMT和APBSCT是治疗急性白血病和恶性淋巴瘤的安全、有效方法。Objective\ To evaluate the efficacy of autologous bone marrow transplantation and autologous hematopoietic stem cell transplantation for patients with acute leukemia and malignant lymphoma.\ Methods\ Six patients with acute leukemia and four with malignant lymphoma were treated with autologous bone marrow transplantation(ABMT) or autologous peripheral blood stem cell transplantation(APBSCT) ,all patients were followed up for 1.0-4.3 years.\ Results\ The hematopoiesis recovered in all patients, no transplantation related death, median time for the recovery of neutrophils to>0.5×10 9/L in ABMT and APBSCT were 12(9-15) days and 10(9-12) days, platelet >20×10 9/L were 16(13-22) days and 13(8-41)days ,respectively. Four patients survive with disease free (1.3-4.3 years), six patients relapsed after transplantation(0.3-3.3 years).The median disease free survival was 1.4(0.3- 4.3 ) years.\ Conclusion\ ABMT and APBSCT are safe and efficacious in patients with acute leukemia and malignant lymphoma.

关 键 词：骨髓移植 造血干细胞移植 自体 白血病 非淋巴细胞移植 急性 淋巴瘤 ABMT APBSCT 

分 类 号：R733[医药卫生—肿瘤]