碳铂壳聚糖缓释微球制备时的粒径控制  

The Granule Diameter Control of the Slow-released Microsphere Preparation of Carbonplatin Chitosan

作　　者：徐蔚[1] 曹毅[1] 张纪[2] 

机构地区：[1]昆明医学院第二附属医院神经外科,昆明650101 [2]中国人民解放军总医院神经外科,北京100853

出　　处：《昆明医学院学报》2001年第3期30-34,共5页Journal of Kunming Medical College

摘　　要：为了探讨碳铂缓释微球的制备及其粒径的控制方法 ,采用壳聚糖作为碳铂药物的载体 ,以化学交联技术 ,经戊二醛交联固化可得到结构较为致密 ,球形及载药量均较为理想的微球 .药物的理化品质、载体的机能、骨架的类型、药物在微球中的位置及分布、药物与骨架的相互作用、骨架的空隙度及孔道的弯曲度对药物均有不同的影响 .结果表明 :碳铂缓释微球粒径的控制是其成药的关键 ,参照GuptaPK的统计学处理方法 ,引入“理想函数”全面优化微球的制备工艺 ,得到的微球载药量大 ,粒径分布适宜 ,工艺重现性好 .通过多元线性回归分析 ,发现壳聚糖的浓度、固化时间、壳聚糖材料的类型及搅拌速度可能对粒径分布影响较大 (P <0 0 1) ,而壳聚糖的浓度与投药量的比例决定药物的包封率 .To probe into the preparation of carbonplatin slow-released microspheres and its granule control, spherical microspheres with dense structure and good drug loading were obtained with chitosan to be carbonplatin carriers by chemical cross linking and solidifying diadehyde. The drug was found to have varying influence due to the drug′s physicochemical property, carriers′ function, structure types, drug position and distribution in microspheres, patchy degree, hole bending degree and the interaction between drug and structure. The results revealed that the granule diameter control of carbonplatin chitosan was key to the drug. According to the Gupta PK′s statistic process, the 'ideal function' was to deal with the microsphere manufactory process. The final chitosan polymer microsphere had a large capacity to carry drug and had a suitable microsphere diameter.

关 键 词：碳铂 缓释微球 粒径 制药 壳聚糖 抗癌药 

分 类 号：R979.1[医药卫生—药品] R944.9[医药卫生—药学]