预激综合征与染色体7q3连锁  

Pre-excitation syndrome linked to chromosome 7q3

作　　者：刘文玲[1] 刘国树[1] 胡大一[2] 戚豫[3] 单兆亮[1] 刘德强[4] 杨大严 王玉梅 王莉[1] 易军[1] 骆雷鸣[1] 

机构地区：[1]解放军总医院心内科,北京100853 [2]北京大学人民医院心内科 [3]北京大学第一临床医院中心实验室 [4]河北邯郸市第一医院医务科 [5]安徽濉溪县医院心内科 [6]河北衡水市桃城区妇幼保健医院儿科

出　　处：《中华心血管病杂志》2001年第10期593-596,共4页Chinese Journal of Cardiology

摘　　要：目的　探寻预激综合征的致病基因。方法　应用基因分型的方法 ,以 7q3上D7S5 0 5、D7S6 88和D7S483为候选位点 ,对 3个家族性预激综合征家系 (共 10 1例成员 )进行了连锁分析。结果　家族性预激综合征与上述 3个位点均连锁 ,以D7S5 0 5Lod值最高 ,重组率 (θ)为 0 1时Lod =6 4 ;D7S483和D7S6 88位点Lod值分别为 2 5和 5 3。结论　预激综合征的相关基因位于 7q3上。Objective To localize the genetic loci of the pre-excitation syndrome. Methods Linkage analysis between the disease of the pre-excitation syndrome and 3 STR(short tandem repeats)markers on chromosome 7q3(D7S505, D7S688, and D7S483) were tested in 3 kindreds of the pre-excitation syndrome (101 persons in total)by genotyping. Results The disease was linked to the loci above. The maximum two-point Lod score detected at D7S505 was 6.4 at a recombination fraction (θ)of 0.1;the Lod scores of D7S688 and D7S483 were 5.3 and 2.5, respectively.Conclusion The gene of pre-excitation syndrome located at 7q3.

关 键 词：预激综合征 遗传学 染色体7q3连锁 诊断 

分 类 号：R541.7[医药卫生—心血管疾病]