溃疡性结肠炎合并原发性硬化性胆管炎的临床特点研究  

Study of clinical features in patients with ulcerative colitis accompanied by primary sclerosing cholangitis

作　　者：张开光[1] 殷保书[1] 杨仁松[1] 王巧民[1] 郑邦海[1] 贾勇[1] 吴正祥[1] 

机构地区：[1]安徽省立医院消化科,安徽合肥230001

出　　处：《罕少疾病杂志》2001年第2期7-8,共2页Journal of Rare and Uncommon Diseases

摘　　要：目的 分析溃疡性结肠炎 (UC)患者 AKP升高的主要原因、 UC合并原发性硬化性胆管炎 (PSC)的临床特点。 方法 调查了我院近 5年的 UC患者，对 293例 UC患者中 AKP升高者作内窥镜逆行性胰胆管造影 (ERCP)检查，筛选出 PSC患者并进行相关临床特点分析。 结果 293例 UC患者中， 48例 AKP升高，其中 15例诊断为 PSC。患病率为 5.2％。 UC合并 PSC与不合并 PSC的患者的结肠炎的严重程度及部位无显著性差异。 UC合并 PSC患者的肝功能损害以 AKP升高为主， ALT或 AST、白蛋白的改变较轻。 结论 PSC是 UC患者 AKP升高的主要原因之一。对于 UC患者出现不能解释的 AKP升高应予 ERCP检查。Objective To assess the cause of AKP rising in patients with ulcerative colitis(UC) and to explore the clinical manifestations of UC patients accompanied by primary sclerosing cholangitis(PSC). Methods 293 UC patients were tested by AKP,and then,the cases of abnormal AKP were examined by ERCP. Results of 293 UC patients,48 had a high AKP concentration.Out of 48,15 patients were made a diagnosis of PSC by ERCP which characterized by inflammation and stricturing of the extrahepatic bile duct and ocoured in 5.2％ UC patiens.AKP rising in PSC accounted for 31.3％ abnormality of AKP in UC patients.There were no significant differences between two groups as for severity of colitis.PSC patients had a mild changes of ALT or AST. Conclusion PSC is one of the common reasons for abnormal AKP in UC patients.The UC cases of high AKP should be suggested to have ERCP examined.

关 键 词：溃疡性结肠炎 硬化性胆管炎 内窥镜逆行性胰胆管造影 碱性磷酸酶 

分 类 号：R574.620.6[医药卫生—消化系统] R575.7[医药卫生—内科学]