低度恶性纤维黏液样肉瘤2例报道及文献复习  

Low-grade fibromyxoid sarcoma: Report of two cases and review of literature

作　　者：李国红[1] 陆江阳[1] 王晓虹[1] 杨毅[1] 李玲[1] 杨建法[1] 

机构地区：[1]解放军三○四医院病理科,北京100037

出　　处：《诊断病理学杂志》2001年第3期146-148,共3页Chinese Journal of Diagnostic Pathology

摘　　要：目的　探讨低度恶性纤维黏液样肉瘤 (LGFS)的临床病理特点、诊断和预后。方法　对 2例LGFS进行光镜、电镜、组化和免疫组化观察并结合文献进行分析。结果　肿瘤由纤维性区和黏液样区混合构成 ,二者呈交错相间排列 ;纤维性区瘤细胞呈旋涡状排列 ;黏液样区瘤细胞散在 ;细胞核轻度异型 ;PAS染色黏液样区和肿瘤细胞浆内均为阴性。免疫组化标记vimentin、NSE阳性。电镜观察瘤细胞呈纤维母细胞与肌纤维母细胞的特点。结论　LGFS是一种来源于纤维母细胞独立存在进展缓慢的低度恶性软组织肉瘤 ,易误诊为良性。病理诊断依赖于组织学、免疫组化和电镜观察 。Objective To investigate the clinical pathological characteristics, diagnosis and prognosis of low grade fibromyxoid sarcoma (LGFS). Methods Two cases of LGFS were analyzed with light and electron microscopic observation, histochemical and immunohistochemical stains and literature review. Results The tumor comprised a variably proportional mixture of fibrous and myxoid areas, the former showing a whorled growth pattern with mild atypia. Both the myxoid stroma and cell component were negative for PAS staining, but the tumor cells were positive for vimentin and NSE. Electron microscopic examination revealed that the tumor cells had the features of fibroblast and myofibroblast. Conclusions LGFS is a newly recognized low grade sarcoma of fibroblast origin, and can be misdiagnosed as many benign lesions. Pathological diagnosis is based on its morphology, immunohistochemical and ultrastructural findings. Electron microscopy may play an important role in the differential diagnosis.

关 键 词：低度恶性纤维黏液样肉瘤 软组织肉瘤 诊断 鉴别诊断 

分 类 号：R730.262[医药卫生—肿瘤]