侧脑室注射血管紧张素Ⅱ促进内源性洋地黄样因子释放  

Intracerebroventricular administration of angiotensin Ⅱ triggers rele ase of endogenous digitalis-like factor

作　　者：张成标[1] 王勇[1] 陈远寿[1] 魏振宇[1] 王箐[1] 任伟[1] 

机构地区：[1]遵义医学院生理学教研室,贵州遵义563003

出　　处：《遵义医学院学报》2001年第3期213-216,共4页Journal of Zunyi Medical University

基　　金：贵州省教育厅科研基金项目 ( 90 3 3 )

摘　　要：目的　探讨侧脑室注射血管紧张素Ⅱ对内源性洋地黄样因子 (EDLF)释放的影响。方法　大鼠侧脑室注射血管紧张素Ⅱ及侧脑室注射Saralasin或损毁第三脑室前腹区 (AV3V)预处理 ,放射免疫方法测定血清EDLF浓度的变化。结果　侧脑室注射AngⅡ可引起血清EDLF浓度升高 ;Saralasin预处理或海人酸损毁AV3V区可阻断侧脑室注射AngⅡ引起的血清EDLF升高效应。Experiments were performed on anesthetized SD rats. After itracereb roventricular(icv) injection of angiotensin Ⅱ(AngⅡ,100ng/rat), serum endogen ous digitalis like factor(EDLF) concentration increased obviously. These effec ts could be antagonized by icv pretreatement of saralasin, a AngⅡ receptor ant agonist(1μg/rat) or by the anteroventral third ventricle(AV3V) lesions. These results suggest icv injection of Ang Ⅱ induces EDLF release.

关 键 词：血管紧素Ⅱ 侧脑室 第三脑室前腹区 内源性洋地黄样因子 

分 类 号：R335[医药卫生—人体生理学]