万拉法新与帕罗西汀治疗抑郁症的对比研究  

A Controlled Study of the Efficacy of Venlafaxin Capsules and Paroxetine Tablets in the Treatment of Depression

作　　者：陈海支[1] 陈胜华[1] 李新胜[1] 林敬华[1] 

机构地区：[1]湖北省十堰市东风公司茅箭医院精神科,442012

出　　处：《医药导报》2001年第8期488-489,共2页Herald of Medicine

摘　　要：目的 :比较万拉法新与帕罗西汀治疗抑郁症的疗效和安全性。方法 :将 68例患者随机分为两组 ,分别给予万拉法新及帕罗西汀治疗 ,于治疗前及治疗后 1,2 ,4,6周末分别用汉密尔顿抑郁量表 (HAMD)、临床疗效总评量表(CGI SI)及不良反应量表 (TESS)评定。结果 :第 2周末两组间HAMD评分差异有显著性 (P <0 .0 5 )。两组总有效率及副作用差异无显著性 (P >0 .0 5 )。结论 :万拉法新抗抑郁作用起效较快 ,疗效及副作用与帕罗西汀相当。Objective:To compare the efficacy and safety of venlafaxine capsules and paroxetine tablets in the treatment of depression. Methods:68 subjects with depression were randomly divided into two groups and treated with venlafaxine capsules or paroxetine tablets, respectively, for 6 weeks. HAMD, CGL-SI, and TESS were used to evalate the patients at the 1st, 2nd, 4th and 6th week post-treatment. Result:The therapeutic efficacy was significantly different between the two groups(P<0.05). Conclusions:Venlafaxine capsule was a quicker agent than paroxetine tablet in respect of its effect. Both venlafaxine capsules and paroxetine tablets were effective and safe for the treatment of patients with depression.

关 键 词：万拉法新 帕罗西汀 抑郁症 药物疗法 治疗 对比研究 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R971.43[医药卫生—临床医学]