多重肿瘤抑制基因在喉癌中的表达及意义  

Expression of MTS1/P_(16) in Laryngeal Squamous Cell Carcinoma and Its Significance

作　　者：万福生[1] 曾昭建[1] 万义福[2] 

机构地区：[1]江西医学院生化与分子生物学教研室,江西南昌330006 [2]江西省肺科医院,江西南昌330008

出　　处：《江西医学院学报》2000年第1期13-14,共2页Acta Academiae Medicinae Jiangxi

摘　　要：为探讨多重肿瘤抑制基因 (MTS1)与喉状细胞癌生物学行为及预后的关系 ,采用免疫组化 SP法对 32例喉癌组织中 P1 6 蛋白的表达进行检测。结果显示 :32例喉癌中 P1 6 蛋白表达的阳性率为 40 .6 3% ,其阳性表达与肿瘤的病理分级、临床分期及预后密切相关 ,具有显著性差异 (P<0 .0 5 )。提示 MTS1基因在抑制喉癌的发生、发展中起重要作用 ,可作为喉癌生物学行为及预后评估的参考指标。In order to study the relation of multiple tumor supressor 1(MTS1/P 16 )to the biological behavior and prognosis, the expression of suppressor gene P 16 was investigated by immumohistocheminal S P method in 32 cases of laryngeal squamous cell carcimoma (LSCC).The results showed that the positive rate of P 16 protein was 40.63% in 32 cases of LSCC,closely related to pathological grading,clinical staging and prognosis of the carcinoma with significant difference ( P <0.05).It is suggested that P 16 plays an important role in supressing the development of LSCC,and can be used as a referenee index for evaluating the biological behavior and prognosis of laryngeal squamous cell careinoma.

关 键 词：喉肿瘤 P16蛋白 免疫组织化学 肿瘤抑制基因 MTS1 

分 类 号：R730.3[医药卫生—肿瘤] R739.65[医药卫生—临床医学]