体内性激素与鼻咽血管纤维瘤的临床研究  

Clinical Study on Relationship between Nasopharyngeal Angiofibroma and Serum Sex Hormones

作　　者：祝小林[1] 刘少英[1] 李外苟[2] 龙平[3] 

机构地区：[1]江西医学院第二附属医院耳鼻咽喉科教研室,江西南昌330006 [2]江西医学院核医学教研室,江西南昌330006 [3]江西医学院第一附属医院耳鼻咽喉科教研室,江西南昌330006

出　　处：《江西医学院学报》2000年第3期13-15,共3页Acta Academiae Medicinae Jiangxi

基　　金：江西省科委课题

摘　　要：目的 :探讨鼻咽血管纤维瘤与体内性激素的临床关系。方法 :采集 2 4例鼻咽血管纤维瘤患者手术前后外周静脉血标本 (术前 2 4例 ,术后 2 0例 )及 2 4例健康男性青年作为对照组 ,用放射免疫测定法分别检测鼻咽血管纤维瘤患者手术前后及对照组血清性激素水平。结果 :①鼻咽血管纤维瘤患者手术前后血清性激素水平变化不大 (P >0 .0 5 ) ;②血清雌二醇、孕酮术前水平较正常对照组低 (P <0 .0 5 ) ,血清睾酮术前水平与正常对照组水平变化不大(P >0 .0 5 ) ;③鼻咽血管纤维瘤患者术后性激素水平与正常对照组水平变化不大 (P >0 .0 5 )。结论 :鼻咽血管纤维瘤发病机制与体内性激素水平可能存在一定程度的相关关系。Objective:To evaluate the relationship between juvenile nasopharyngeal angiofibroma (JNA) and serum sexual hormones. Methods: The serum sexual hormones levels were determined in 24 cases of JNA before operation using radial immunoassay, they were determined again after operation in 20 of the patients, and 24 healthy young men were taken as control. Results: (1)The changes of serum testosterone, estrogen and progestin levels in JNA group were not significant between pre- and postoperative period (P>0.05). (2)Before operation, the serum estrogen and progestin levels in JNA group were lower significantly than that in control group(P<0.05), and there was not significant change of serum testosterone level between two group (P> 0.05) . (3)After operation, there were not significant changes of serum sexual hormones levels between JNA group and control group (P>0.05). Conclusion: The results suggested there was certain relationship between the pathogenesis of JNA and serum sexual hormones.

关 键 词：鼻咽肿瘤 性激素 放射免疫测定法 病理学 

分 类 号：R739.63[医药卫生—肿瘤]