侧链含有鬼臼毒素高分子抗癌药物的合成  

SYNTHESIS OF THE POLYMERIC ANTICANCER DRUGS COVALENTLY LINKED PODOPHYLLOTOXIN

作　　者：李天锡[1] 袁才英 

机构地区：[1]兰州医学院药学系药物化学教研室,兰州730000 [2]甘肃神龙药业股份有限公司技术中心,兰州730046

出　　处：《天然产物研究与开发》2001年第5期63-65,共3页Natural Product Research and Development

摘　　要：分别用可溶性淀粉、羧甲基纤维素钠和甲壳胺为载体与鬼臼毒素合成了三种侧链含有鬼臼毒素高分子抗癌药物。在pH 7.4的缓冲溶液中对鬼臼毒基羰甲基淀粉 。Three series of macromolecular drugs covalently linked podophyllotoxin are synthesized by the use of soluble starch,carboxylmethylcellulose and chitosan as carries.The hydrolysis delivery of podophyllotoxin from soluble starch,CMC Na and chitosan in buffer(pH 7.4)was researched.

关 键 词：鬼臼毒素 高分子载体药物 可溶性淀粉 羧甲基纤维素钠 甲壳胺 高分子抗药癌 合成 侧链 

分 类 号：R979.1[医药卫生—药品] R914.5[医药卫生—药学]