口服乙酰唑胺负荷试验SPECT脑灌注显像早期诊断TIA的价值  

The early diagnostic value of oral acetazolamide load combined with SPECT rCBF imaging in patients with transient ischemia attack in brain

作　　者：刘新通[1] 郑芷萍[1] 乔穗宪[2] 唐安戊[2] 

机构地区：[1]广东省人民医院神经内科,广州510080 [2]广东省人民医院核医学科,广州510080

出　　处：《中华核医学杂志》2001年第4期236-237,共2页Chinese Journal of Nuclear Medicine

摘　　要：目的　评价口服乙酰唑胺 (ACZ)脑负荷试验SPECT脑灌注显像对短暂性脑缺血发作(TIA)患者的诊断价值。方法　 10例正常志愿者和 30例TIA患者进行静息和口服ACZ脑负荷试验SPECT显像。并进行视觉及半定量分析 ,观察口服ACZ前后血气分析变化。结果　正常ACZ脑负荷试验后99Tcm 双半胱乙酯 (ECD)在大脑两侧对应部位呈对称分布 ,脑血流普遍增加 ;TIA组ACZ脑负荷试验后 ,血pH值降低 ,PCO2 增高。TIA患者ACZ脑负荷试验后总阳性率为 93%。结论　口服ACZ脑负荷试验方法简单可靠 ,对TIA患者早期的影像学诊断有重要价值。Objective In order to assess the diagnostic value of acetazolamide (ACZ) combined with rCBF SPECT imaging in patients with transient ischemia attack (TIA). Methods SPECT imaging was performed before and after oral ACZ with visual and semiquantitative analysis of the images. Blood gas analysis was done before and after ACZ administration either. Results After ACZ loading,in normal group, 99 Tc m ECD was distributed symmetrically on correspondent parts of the brain and rCBF was generally increased .The blood pH was decreased and blood PCO 2 was increased, respectively in TIA group,the positive rate of hypoperfusion foci on SPECT images were increased from 5/6 to 6/6 in symptomatic patients and from 60% to 92% in asymptomatic patients. The total positive rate was 93%. Conclusion Oral ACZ before SPECT imaging is a simple,reliable way for early diagnosis in patients with TIA.

关 键 词：脑缺血 暂时性 乙酰唑胺 SPECT 早期诊断 

分 类 号：R743[医药卫生—神经病学与精神病学]