甲状腺嗜酸细胞腺瘤的临床病理分析  

Clinicopathologic analysis of oxyphilic cell adenoma of the thyroid

作　　者：李春明[1] 王淑琴[1] 丘剑阳[1] 白继花[1] 张景康 

机构地区：[1]晋中市第二人民医院,030800 [2]晋中市卫生学校

出　　处：《山西医药杂志》2001年第5期382-384,共3页Shanxi Medical Journal

摘　　要：目的　观察甲状腺嗜酸细胞腺瘤的病理学特点并结合文献探讨其性质、起源和功能。方法　观察9例甲状腺嗜酸细胞腺瘤 ,在光镜观察的基础上 ,用免疫组织化学方法检测细胞角蛋白、甲状腺球蛋白 ( TG)、神经元特异性烯醇化酶 ( NSE)、波形蛋白和降钙素。结果　甲状腺嗜酸细胞腺瘤以细胞质嗜酸性、粗颗粒为特点 ,细胞形态多样 ,排列成滤泡型、小梁型和实体型 ,细胞角蛋白 ( + ) 8例 ,TG( + ) 7例 ,NSE( + ) 7例 ,波形蛋白 ( + ) 9例 ,降钙素 ( + ) 3例。结论　甲状腺嗜酸细胞腺瘤是有病理形态特点的潜在恶性肿瘤 ,起源于滤泡上皮细胞 ,不具有功能活动 ,区别良恶性不能靠特殊检查 ,要依赖传统的包膜。Objective To observe the pathologic feature of oxyphilic cell adenoma of the thyroid and combined with reviewing the document to inquiry into its quality,origin and function.Method On the basis of light microscopic observation the immunohistochemical examination of CK,TG,NSE,vimentin and calcitonin was used to observe 9 cases of oxyphilic cell adenoma of the thyroid.Results Oxyphilic cell adenoma of the thyroid had strong eosinophilic cytoplasm with coarse granules and morphological variety.It formed follicular,trabecular and solid type.The expression of CK(+)8,TG(+)7,NSE(+)7,vimentin(+)9 and calcitonin(+)3 was positive.Conclusion Oxyphilic cell adenoma of the thyroid is a potential malignant tumor with a defined pathologic feature,it originates in follicular epithelial cell and hasn′t functional activity.To distinguish between the benign and the malignant depends on traditional encapsulation,and whether there is a blood vessel invasion or metastasis.

关 键 词：甲状腺嗜酸细胞肿瘤 病理学 诊断 治疗 

分 类 号：R736.1[医药卫生—肿瘤]