限钠或补钠对充血性心衰大鼠心钠素及心功能的影响  

Effects of sodium restricted or supplemented on atrial natriuretic polypeptide and cardiac function of rats with congestive heart failure

作　　者：张素珍[1] 徐永[2] 万瑜[3] 杨钢[3] 胡建民[4] 徐芳玲[3] 

机构地区：[1]广东医学院病理生理学教研室,广东湛江524023 [2]广东医学院生理学教研室,广东湛江524023 [3]湖北医科大学生理学教研室,湖北武汉430071 [4]湖北医科大学实验研究中心,湖北武汉430071

出　　处：《中国病理生理杂志》2001年第11期1077-1080,共4页Chinese Journal of Pathophysiology

基　　金：湖北省教委青年科研基金资助项目 (No .96C0 5 )

摘　　要：目的 :观察限钠或补钠对充血性心衰大鼠心钠素及心功能的影响。方法 :将充血性心衰大鼠随机分为 3组 (心衰组、心衰限钠组、心衰补钠组 ) ,假手术大鼠为对照组 ,用放射免疫分析法测定各组血浆和心肌心钠素水平 ,同时检测心功能。结果 :心衰限钠组血钠、心房心钠素及左室收缩压和动脉压显著低于心衰组 ,血浆和心室心钠素、右房压均显著高于心衰组 ;心衰补钠组血钠和动脉压与对照组无显著差别 ,血浆和心肌心钠素、右房压与心衰组无显著差别 ,左室收缩压显著高于心衰组 ,左室舒张末压显著低于心衰组。结论 :心衰后适量补钠维持血钠平衡有利于心钠素发挥排钠利尿作用 ,改善心功能。AIM: To observe the effects of sodium restricted or supplemented on atrial natriuretic polypeptide (ANP) and cardiac function of rats with congestive heart failure (CHF).METHODS: CHF rats were divided into three groups with sham operation rats group as control. Radioimmunassay was used to determine the ANP contents of plasma and myocardium, at the same time cardiac function was measured.RESULTS: In sodium restricted group, the plasma sodium and atrial ANP and left ventricular systolic pressure and artery pressure were obviously lower than those in CHF group, while the plasma and ventricular ANP and the right atrial pressure were remarkably higher; In sodium supplemented group, the plasma sodium and arterial pressure had no obvious change compared with the control, the plasma and myocardium ANP and the right atrial pressure had no difference as compared with CHF group, while the left ventricular end diastolic pressure was remarkably lower and the left ventricular systolic pressure were obviously higher. CONCLUSION: Keeping the balance of plasma sodium by an appropriate supplement of sodium intake after CHF might be beneficial to the ANP biological effects and the cardiac function.

关 键 词：充血性心力衰竭 心钠素 限钠 补钠 心功能 大鼠 

分 类 号：R541.61[医药卫生—心血管疾病]