肺癌体外药敏试验与临床疗效的相关性研究  

Study on the relationship between MTT chemosensitivity test and clinical chemotherapy in human lung cancer

作　　者：唐亚辉[1] 马葵[1] 韩居然[1] 黄晋生[1] 王卉[1] 

机构地区：[1]海军总医院血液肿瘤科研究室,北京100037

出　　处：《中国药学杂志》2001年第9期597-599,共3页Chinese Pharmaceutical Journal

摘　　要：目的　采用四唑盐 (MTT)药敏试验方法筛选对肺癌的敏感药物并指导临床化疗。方法　将 145例 4种不同类型的肺癌 ,分别分为MTT试验组和未做MTT试验组。接受MTT药敏试验者 ,根据药敏结果指导化疗 ,未接受MTT药敏试验者凭经验化疗。结果　体外药敏试验与临床治疗结果的总符合率为 89.3% ;阳性符合率为 90 .9% ;阴性符合率为 77.8% ;试验敏感性为 96 .8% ;特异性为 5 3.8%。接受MTT药敏试验者临床治疗有效率明显高于凭经验化疗组。结论　MTT体外药敏试验与临床治疗敏感性有很好的相关性 。OBJECTIVE: To scan the chemosensitivity of drugs for lung cancer by MTT assay in vitro. METHODS: 145 patients with lung cancer, included 4 of types, were divided into two groups. One group were treated according to the results by MTT assay, the other did by empirical regimens without MTT assay. RESULTS: Between the diagnosis in vitro and in vivo, the overall coincident rate was 89.3%, among them the positive rate and negative rate were 90.9% and 77.8%, respectively. The sensitivity and specificity of MTT tests were 96.8% and 53.8%, respectively. CONCLUSION: The in vitro MTT assay may predict the outcome of chemotherapy for patients with lung cancer.

关 键 词：肺癌 药敏试验 MTT法 四唑盐 

分 类 号：R734.2[医药卫生—肿瘤] R73－361[医药卫生—临床医学]