复方美沙芬片的毛细管电泳快速分析  

Simultaneous Determination of Dextromethorphen and Pseudoephedrine in Compound tablets by HPCE

作　　者：季一兵[1] 陈玉英[1] 

机构地区：[1]中国药科大学分析化学教研室,南京210009

出　　处：《中国药科大学学报》2001年第4期276-278,共3页Journal of China Pharmaceutical University

摘　　要：目的　建立了毛细管电泳快速测定复方美沙芬片中有效成分含量的方法 ,讨论了硼酸盐浓度对分离选择性的影响。方法　在 4 0 cm× 5 0μm的未涂层石英毛细管柱上 ,以 1 0 mmol/L硼酸盐为缓冲液 ,2 1 4 nm为测定波长 ,1 0 min之内用内标法测得伪麻黄碱和美沙芬的含量。结果　两组分含量在 98.0 %～ 1 0 1 %之间 ,线性范围分别为 0 .3～ 3 .0 mg/ml和 0 .1～ 1 .0 mg/ml,RSD小于 3 %。结论　该方法可用于复方美沙芬片的质量控制。AIM A HPCE method is developed which can simultaneously deter mi ne for the separation of dextromethorphen and pseudoephedrine in tablets. The i nfluence of borate buffers on the electrophoretic behavior of pseudoephedrine wa s investigated. METHOD\ This method used 10 mmol/L borate as running b uffer, metornidozle as the internal standard, and electrophoretic separation was ach ieved within 10 min. RESULTS\ The precision for each component was bel ow 3%. CONCLUSION\ The development of this method is simple and rapid. It is reliable in quality control of the tablets.

关 键 词：复方美沙芬 片剂 毛细管电泳 快速分析 镇咳药 有效成分 含量测定 

分 类 号：R914[医药卫生—药物化学]