药物制剂辅料β-环糊精的纯化及含量测定  

Purification and Determination of β-cyclodextrins

作　　者：何华[1] 陈颂仪[1] 王宇新[1] 徐存华[1] 

机构地区：[1]中国药科大学,江苏南京210009

出　　处：《药学进展》2001年第4期243-245,共3页Progress in Pharmaceutical Sciences

摘　　要：分别用水、乙醇、丙酮等试剂处理 β-环糊精 (β- CD)产品 ,考察了提高 β- CD纯度的方法 ,并用间接 (褪色 )分光光度法在 5 5 2 nm处测定了 β- CD含量 ,结果发现 ,经纯化处理的 β- CD纯度有不同程度的提高 ,其中以经水二次重结晶、再分别用乙醇和丙酮处理的 β- CD纯度为最高 ,含量平均值为 98.8% (n=4)cyclodextirins(β-CDs), which were purified by wa ter, alcohol and acetone respectively to investigate the method for improving t he purity of β-CDs, were determined by spectrophotometry method based on meas uring the decrease in the absorbance of the phenolphthalein solution at 552nm an d pH10.5 upon the addition of the β-CD solution. Results showed that the puri ties of all treated β-CDs were improved, especially one treated by water,alco hol and acetone with the highest purity of 98.9%( n =4).

关 键 词：Β-环糊精 纯化 分光光度法 含量测定 药物辅料 

分 类 号：O636[理学—高分子化学]