比较基因组杂交研究鼻咽癌遗传变异  

Chromosomal aberration analyzed by comparativegenomic hybridization in nasopharyngeal carcinoma

作　　者：李忠花[1] 王璐[2] 张小慧[1] 张丽君[2] 张必成[1] 余鹰[1] 曾朝阳[1] 周鸣[1] 黄薇[2] 陈竺[2] 陈赛娟[2] 李桂源[1] 

机构地区：[1]中南大学湘雅医学院肿瘤研究所,长沙410078 [2]上海第二医科大学附属瑞金医院血液研究所及遗传教研室,上海200025

出　　处：《中华医学遗传学杂志》2001年第5期338-342,共5页Chinese Journal of Medical Genetics

基　　金：国家"8 63"项目基金 (Z1 9- 0 1 - 0 1 - 0 3和 1 0 2 - 1 0 - 0 1 - 0 5);国家"973"项目基金 (G1 9980 51 0 0 8)

摘　　要：目的　了解鼻咽癌遗传学改变的特征。方法　应用比较基因组杂交检测 2 0例鼻咽癌基因组的不平衡即DNA的丢失或扩增。结果　鼻咽癌常见的扩增的染色体是 1q、2、3q、7q、8q、12 ;常见的缺失的染色体为 3p、9p、11q、16 q。结论　鼻咽癌细胞中存在多条染色体拷贝数的改变 ,由此引起相应瘤基因的扩增和抑癌基因的丢失可能参与了鼻咽癌的发生。Objective: To identify genetic alteration in primary sporadic nasopharyngeal carcinoma (NPC) in Hunan. Methods Comparative genomic hybridization was applied to investigate the genomic imbalance in a series of 20 cases of primary nasopharyngeal carcinomas. Results: The common chromosomal alterations included gains of chromosomes lq, 2, 3q, 7q, 8q, 12 as well as losses of chromosomes 3p, 9p, 11q, 16q. Conclusion: There are multiple regions of chromosomes with copy number changes in NPC. The tumor suppressor genes and oncogenes on these regions may be involved in the development and progress of nasopharyngeal carcinoma.

关 键 词：鼻咽癌 比较基因组杂交 抑瘤基因 瘤基因 

分 类 号：R739.63[医药卫生—肿瘤]