nm23-H_(1)在胃癌中表达的研究  

Study on nm23-H_(1) Expression in Gastric Carcinoma

作　　者：刘晖[1] 胡祥[2] 范跃祖[1] 姬舒荣[1] 

机构地区：[1]同济大学附属同济医院普外科,上海200065 [2]大连医科大学附属第一医院普外科,大连116013

出　　处：《同济大学学报（医学版）》2001年第4期26-27,30,共3页Journal of Tongji University(Medical Science)

摘　　要：目的　分析nm2 3 H1(简称nm2 3 H1)在胃癌分化、浸润转移中的作用及其表达的临床意义。方法　应用ABC免疫组化方法 ,研究 46例原发性胃癌组织及其转移淋巴结nm2 3 H1的表达。结果　 45 .6 % (2 1/ 46 )的胃癌nm2 3 H1表达下降。nm2 3 H1的阳性表达与Borrmann分型、组织学分型无关 (P >0 .0 5 ) ,而与肿瘤大小、胃癌浸润深度、临床病理分期、淋巴结转移密切相关 (P <0 .0 5 )。 5 4%的胃癌原发灶nm2 3 H1蛋白呈阳性表达 ,只有 37.5 %的淋巴结转移灶nm2 3 H1蛋白呈阳性表达。结论　nm2 3 H1可能对胃癌的浸润。Objective To study nm23?H 1 expression in gastric carcinoma and its relation with tumor differentiation, invasion and metastasis.Methods nm23?H 1 expression was detected by using ABC immunohistochemical method.Results 45.6% of the primary tumors ( n =21) showed negative nm23?H 1 expression. No significant correlation was found between positive nm23?H 1 expression and Borrmann classification., histologic classification ( P >0.05). Significant correlation was observed between nm23?H 1 expression and tumor diameter, depth of invasion, clinicopathologic stage, lymph node metastasis ( P< 0.05). 54.0% of gastric carcinomas expressed positive nm23?H 1 at the site of primary tumors. Only 37.5% of the lymph node metastasis showed positive nm23?H 1.Conclusion Decrease of nm23?H 1 expression correlates with depth of invasion and lymph node metastasis, and there is no relationship between nm23?H 1 expression and differentiation of gastric carcinoma.

关 键 词：胃肿瘤 nm23-H_(1) 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]