放热化综合治疗非小细胞肺癌的远期疗效  

Radio-thermo-chemotherapy for lung cancer

作　　者：周桂霞[1] 崔书祥[1] 常庆森[1] 杨东[1] 曾狄闻[1] 赵彼德[2] 郭新娜[2] 

机构地区：[1]解放军总医院放疗科,北京100853 [2]解放军总医院理疗科

出　　处：《军医进修学院学报》2001年第3期199-201,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的 :探讨放热化综合治疗非小细胞肺癌 (NSCLC)的最佳组合、临床方法及远期疗效。方法 :非小细胞肺癌 (NSCLC) 88例 ,其中放热化和单放组各 30例、放热组 2 8例 ;鳞癌 73例、腺癌 14例、类癌 1例。采用常规放射治疗方法 ,每次照射 1 8～ 2Gy ,每周 5次 ,肿瘤照射剂量 5 0～ 70Gy ;使用 8MHz射频热疗机 ,放疗后 30～ 6 0min内热疗 ,持续 6 0min ,肿瘤温度 41～ 43℃ ,每周 2次 ,8～ 12次为一疗程 ;化疗在放疗后、热疗前或热疗中进行 ,每周一次。结果 :总有效率和 1年、3年、5年生存率分别为 :放热化组 70 %、76 7%、43 3%和 2 3 3 % ;放热组 6 7 9%、75 %、32 1%和 14 3% ;单放组 5 3 3 %、6 3 3%、2 0 %和 6 7% ;3和 5年生存率 :放热化组与单放组差异显著 (P <0 0 5 )。死亡 6 7例、8例失访 ;死亡原因为远地转移 33例 ;局部复发 2 6例 ;非癌性死亡 8例。结论 :放热化综合治疗对降低NSCLC远地转移和肿瘤局部复发具有一定临床价值 ,是一条能提高远期生存率的有效治疗方法。Objective:To explore the effect of this combination treatment on lung cancer and their different optimal matched method Methods: 88 lung cancer patients(squamous carcinoma 73,adenocarcinoma 14,carcinoid 1) were randomly divided into three groups: radio thermo chemotherapy group for 30 cases, radio thermotherapy group 28 cases and radiotherapy alone group 30 cases The radiation dose was 60 70Gy in radiotherapy group and 50 60Gy in the other two groups The thermotherapy was performed 30 60min after radiotherapy treatment for 60 min twice a week, for 8 12 times The tumor temperature reached 41℃ 43℃ Chemotherapy composed of DDP,VCR,CTX and ADM was performed between the radiation and thermotherapy or after thermotherapy once a week The chest CT was measured and compared before and after the treatment Results: The effective rate and 1,3,5 year survival were 70%,76 7%,43 3% and 23 3% in radio thermo chemotherapy group;67 9%,75%,32 1% and 14 3% in radio thermotherapy group;53 3%,63 3%,20% and 6 7% in radiation group Survival in radio thermo chemotherapy group was higher than radiation alone group at 3,5 years ( P <0 05, using χ 2 test) Conclusion: The effect of radio thermo chemotherapy is superior to that of radiotherapy alone for lung cancer and is a good treatment method to improve the survival

关 键 词：非小细胞肺癌 药物治疗 放射治疗 热疗法 综合治疗 

分 类 号：R734.2[医药卫生—肿瘤] R730.5[医药卫生—临床医学]