左旋氧氟沙星滴眼液治疗细菌性结膜、角膜炎的临床疗效  

Clinical Effects of Levofloxacin Eyedrops in the Treatment of Acute Bacterial Conjunctivitis and Keratitis

作　　者：袁长明[1] 李嘉文[1] 张莉玲[1] 过巧珊[1] 杨晏[1] 

机构地区：[1]重庆市急救医疗中心,重庆市400014

出　　处：《中国药房》2001年第6期364-365,共2页China Pharmacy

摘　　要：目的 :了解国产0 3 %左旋氧氟沙星滴眼液治疗急性细菌性结膜炎、角膜炎的临床疗效。方法 :确诊病例分层随机加入试验组及对照组 ,对照药物为0 3 %氧氟沙星滴眼液 ,对比观察疗效及毒副作用并作统计学分析。结果 :1998年4月～12月共观察132例 ,其中试验组67例 ,对照组65例。各组细菌培养阳性率均为80 %以上 ,两组的痊愈率及有效率无显著性差异 ,但左旋氧氟沙星的最低抑菌浓度更低 ,角膜炎病例中试验组的平均治愈日数明显少于对照组。结论 :0 3 %左旋氧氟沙星滴眼液对细菌性角膜炎、结膜炎疗效好、疗程短 ,无明显不良反应 ,有临床应用价值。OBJECTIVE:To observe the therapeutic effects of 0 3% levofloxacin eyedrops on the acute bacterial conjunctivitis and keratitis METHODS:The patients were randomly divided into treated group and control group They were given 0 3% levofloxacin and 0 3% ofloxacin eyedrops respectively The effects were compared between two groups RESULTS:From April 1998 to December 1998,132 cases were enrolled in the study:treated group 67 cases,control group 65 cases The positive rates of bacterial culture were over 80% in both groups It showed that there was no significant difference between two eyedrops in the curative and effective rates,but the mean cure day of keratitis in levofloxacin group was significantly shorter than that in ofloxacin group CONCLUSION:Levofloxacin eyedrops is effective and safe in treating bacterial conjunctivitis and keratitis,and the therapeutic course is short and no obvious ARDs occur

关 键 词：左旋氧氟沙星滴眼液 结膜炎 角膜炎 治疗 

分 类 号：R772.210.5[医药卫生—眼科]