放疗加化疗治疗晚期鼻咽癌的临床分析  

Clinical Analysis of Treatment for Advanced Nasopharyngeal Carcinoma with Radiotherapy Plus Chemotherapy

作　　者：张九成[1] 冯纪祥[1] 李长青[1] 

机构地区：[1]湖北省肿瘤医院,武汉430079

出　　处：《肿瘤防治研究》2001年第5期401-402,共2页Cancer Research on Prevention and Treatment

摘　　要：目的　评价综合治疗晚期鼻咽癌的疗效。方法　 1 993年 3月至 1 996年 3月 ,1 88例 、 a期鼻咽癌患者随机分为两组 (化放组和放疗组 ) ,每组 94例。放疗用 60 Co机或直线加速器照射。鼻咽癌原发灶 DT68～ 76Gy/7- 7.5 w,颈部 DT5 0～ 70 Gy/5 - 7w。化疗组在放疗前和放疗后分别用 PDD+ 5 - Fu方案化疗。结果　 3、5年生存率放化疗组分别为 68.1 %、5 5 .3% ,放疗组分别为 5 4 .2 %、37.2 % ;远处转移率化放组为 35 .1 % ,放疗组为 47.9% ,统计学上都有显著性差异 ( P<0 .0 5 )。Objective TO evaluate effect of radiotherapy plus chemotherapy in advanced nasopharyngeal carcinoma.Methods From March 1993 to March 1996,188 patients in Ⅲ?Ⅳa stage were divided randomly into two groups.Radiotherapy group (94 cases) was only treated by cobalt 60 or linear accelerator with D T68~76GY/7 7.5w in nasopharynx and D T50~70GY/5 7w in the neck.Chemo radiotherapy therapy group(94 cases) received chemotherapy with PDD+5 Fu before radiotherapy and after rediotherapy.Results The 3?5 year survival rates were 68.1%?55.5% in chemotherapy plus radiotherapy group and 54.2%?37.2% in radiotherapy group;Distant metastasis rates were 35.1% in chemotherapy plus radiotherapy group and 47.5% in radiotherapy group respectively with significant difference between the two groups (P<0.05) .Conclusion Radiotherapy plus chemotherapy can increase the survival rates and decrease distant metastasis rates for advanced nasopharyngeal carcinoma.

关 键 词：鼻咽癌 生存率 远处转移率 放射疗法 药物疗法 

分 类 号：R739.63[医药卫生—肿瘤] R730.5[医药卫生—临床医学]